Endothelial dysfunction in COVID-19 patients and clinical application of laser therapy

Kochetkov AV1,2, Ponomareva NYu2, Kadnikova NG2, Mitkovskij VG1,2, Yampolskaya EN2, Lazarev VV2
About authors

1 Academy of Postgraduate Education FNSC FMBA of Russia, Moscow, Russia

2 Central Clinical Hospital for the Rehabilitation of FMBA of Russia, Solnechnogorsk District, Moscow Region, Russia

Correspondence should be addressed: Andrey V. Kochetkov
Volokolamskoe shosse, 91, Moscow, 125371; ur.xobni@voktehctok

About paper

Author contribution: AV Kochetkov — idea, data analysis and interpretation; NYu Ponomareva — literature analysis, manuscript drafting; NG Kadnikova — laser therapy technique application, data collection; VG Mitkovskij — research organization task setting; EN Yampolskaya — research results analysis and interpretation; VV Lazarev — selection of patients for application of the technique, analysis of the results.

Received: 2020-11-09 Accepted: 2020-11-24 Published online: 2020-12-19

This review covers the published papers describing endothelial dysfunction pathogenesis and molecular mechanisms behind the effect of low-level laser therapy on regulation of the said pathogenesis. Herein, we present the current experience of using laser therapy to prevent development of endothelial dysfunction in the context of post-COVID-19 rehabilitation, as well as the accumulated data on the methods of combination of external or intravenous laser blood therapy and influence on the immunocompetent. We provide justification for practicing personalized approach at various stages of post-COVID-19 rehabilitation and treatment. The basis allowing greater efficacy of post-COVID-19 rehabilitation, including protocols making use of laser therapy, is the analysis of single-nucleotide polymorphisms of genes that determine adaptation processes, peculiarities of the immune response to infectious pathogens, predisposition to the development of respiratory distress syndrome, severe pneumonia, sepsis, multiple organ failure, development of endothelial dysfunction, thrombotic complications, the analysis that allows identification of patients running higher risk of critical conditions.

Keywords: genotyping, endothelial dysfunction, COVID-19, rehabilitation treatment, laser therapy, personalized approach