ORIGINAL RESEARCH

Adaptation to intermittent hypoxia: dynamics of blood oxygen saturation and some hematological parameters

Katuntsev VP, Zakharov SYu, Sukhostavtseva TV, Puchkova AA
About authors

Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Correspondence should be addressed: Vladimir P. Katuntsev
Dyshinskaya, 14, kv. 82, Moscow, 111024; ur.xednay@takpv

About paper

Funding: the study was carried out under the State Assignment for FMBA, with no additional funding.

Acknowledgements: the authors thank all volunteers who participated in this study.

Author contribution: Katuntsev VP conceived and designed the study, wrote the manuscript; Zakharov SYu, Sukhostavtseva TV, Puchkova AA collected and analyzed the obtained data; Sukhostavtseva TV performed statistical analysis; Zakharov SYu, Sukhostavtseva TV edited the manuscript.

Received: 2020-09-07 Accepted: 2020-11-17 Published online: 2020-11-30
|
  1. Sirotinin NN. Zhizn' na vysotah i bolezn' vysoty. Kiev: Izd-vo AN USSR, 1939; 226 s. Russian.
  2. Barbashova ZI. Akklimatizacija k gipoksii i ee fiziologicheskie mehanizmy. L.: Nauka, 1960; 216 s. Russian.
  3. Van Lir Je, Stiknej K. Gipoksija. M.: Medicina, 1967; 368 s. Russian.
  4. Agadzhanjan NA, Mirrahimov MM. Gory i rezistentnost' organizma. M.: Nauka, 1970; 182 s. Russian.
  5. Kovalenko EA. Gipoksicheskaja trenirovka v medicine. Hypoxia Medical Journal. 1993; 1 (1): 2–4. Russian.
  6. Berezovskij VA, Levashov MI. Vvedenie v oroterapiju. Kiev: Izd. Akademii problem gipoksii RF, 2000; 76 s. Russian.
  7. Zagajnaya EYe, Shhekochihin DYu, Kopylov FYu, Glazachev OS, Syrkin AL, Sazontova TG. Interval'nye gipoksicheskie trenirovki v kardiologicheskoj praktike. Kardiologija i serdechno-sosudistaja hirurgija. 2014; 6: 28–34. Russian.
  8. Serebrovskaya TV, Shatilo VB. Opyt ispol'zovanija interval'noj gipoksii dlja preduprezhdenija i lechenija zabolevanij serdechno-sosudistoj sistemy. Obzor. Krovobig ta gemostaz. 2014; 1–2: 16–33. Russian.
  9. Gridin LA. Sovremennye predstavlenija o fiziologicheskih i lechebno-profilakticheskih jeffektah dejstvija gipoksii i giperkapnii. Medicina. 2016; 3: 45–67. Russian.
  10. Kurdanova MH, Beslaneev IA, Kurdanova MdH, Batyrbekova LM, Kurdanov HA. Sistemnyj analiz nejrovegetativnoj reguljacii, funkcii jendotelija i tireoidnogo statusa u zdorovyh lic v uslovijah vysokogor'ja. Aviakosmicheskaja i jekologicheskaja medicina. 2019; 53 (1): 66–73. Russian.
  11. Meerson FZ. Obshhij mehanizm adaptacii i profilaktiki. M.: Medicina, 1973; 360 s. Russian.
  12. Meerson FZ. Adaptacija, stress i profilaktika. M.: Nauka, 1981; 78 s. Russian.
  13. Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiological reviews. 2012; 92 (3): 967–1003.
  14. Semenza GL. Transcriptional regulation by hypoxia-inducible factor 1. Molecular mechanisms of oxygen homeostasis. Trends in Cardiovascular Medicine. 1996; 6 (5): 151–7.
  15. Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology. 2008; 24: 97–106.
  16. Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood reviews. 2013; 27 (1): 41–53.
  17. Weil JV, Jamieson G, Brown DW, Grover RF. The red cell mass-arterial oxygen relationship in normal man: application to patients with chronic obstructive airway disease. The Journal of Clinical Investigation. 1968; 47: 1627–39.
  18. Sirotinin NN. Patogennoe dejstvie atmosfery. V knige: Gorizontov ND, Sirotinin NN, redaktory. Patologicheskaja fiziologija jekstremal'nyh sostojanij. M.: Medicina, 1973; s. 36–70. Russian.
  19. Beall CA, Goldstein MC. Hemoglobin concentration, oxygen saturation and arterial oxygen content of Tibetan nomands at 4850 to 5450 m. In: Sutton JR, Coates GC, Remmers JE. Hypoxia: The Adaptations. Toronto & Philadelphia: B.C. Decker Inc., 1990; р. 59–65.
  20. West JB. High-altitude medicine. American Journal of Respiratory and Critical Care Medicine. 2012; 186 (12): 1229–37.
  21. Colleen GJ, Gore CJ, Randall L, Wilber RL, Daniels JT, Fredericson M et al. Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners. Journal of Appl Physiol. 2004; 96: 1800–7.
  22. Core CJ, Rodriguez FA, Truijens MJ, Townsend NE, Stray- Gundersen J, Levine BD. Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4000-5,500 m). Journal of Appl Physiol. 2006; 101: 1386–93.
  23. Serebrovskaya TV, Nikolskij IS, Ishhuk VA, Nikolskaya VV. Adaptacija cheloveka k periodicheskoj gipoksii: vlijanie na gemopojeticheskie stvolovye kletki i immunnuju sistemu. Vestnik Mezhdunarodnoj akademii nauk (russkaja sekcija). 2010; 2: 12– 18. Russian.
  24. Garcia N, Hopkins SR, Power FL. Intermittent vs. continuous hypoxia: effect on ventilation and erythropoiesis in humans. Wilderness & Environmental Medicine. 2000; 11: 172–9.
  25. Glazachev OS, Dudnik EN. Mediko-fiziologicheskoe obosnovanie primenenija gipoksicheski-giperoksicheskih trenirovok v adaptivnoj fizicheskoj kul'ture. Adaptivnaja fizicheskaja kul'tura. 2012; 1 (49): 2–4. Russian.
  26. Faiss R, Girard O, Millet GP. Advancing hypoxic training in team sports: from intermittent hypoxic training to repeated sprint training in hypoxia. Br J Sports Med. 2013; 47: i45–i50.
  27. Ushakov IB, Usov VM, Dvornikov MV, Buhtiyarov IV. Sovremennye aspekty problemy gipoksii v teorii i praktike vysotnoj fiziologii i aviacionnoj medicine. V knige: Lukjanova LD, Ushakov IB, redaktory. Problemy gipoksii. M., 2004; s. 170–200. Russian.
  28. Lukjanova LD. Signal'nye mehanizmy gipoksii. M.: RAN, 2019; 215 s. Russian.
  29. Tarasova AS, Vodjaga VK, Elizarov AN, Kovalenko EA. K voprosu ob ispol'zovanii gipoksicheskogo testa v uslovijah nizkogornogo kurorta Kislovodsk. Hypoxia Medical Journal. 1995; 3: 9–10. Russian.
  30. Haider T, Casucci G, Linser T, Faulhaber M, Gatterer H, Ott G, et al. Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease. Journal of Hypertension. 2009; 27: 1648–54.
  31. Torchilo VV. Ocenka i prognozirovanie jeffektivnosti gipobaricheskoj gipoksii dlja optimizacii rabotosposobnosti operatorov aviacionnoj profilja [dissertacija]. SPb., 2001. Russian.
  32. Wilber RL. Application of Altitude. Hypoxic training by elite athletes. Medicine & Science in Sports & eExercise. 2007; 39 (9): 1610–24.
  33. Kotov OV. Gipoksicheskaja trenirovka i jelektroimpul'snaja reguljacija v sisteme medicinskoj reabilitacii posle vozdejstvija faktorov kosmicheskogo poleta [dissertacija]. SPb., 2010. Russian.
  34. Lesova EM, Samojlov VO, Filippova EB, Savokina OV. Individual'nye razlichija pokazatelej gemodinamiki pri sochetanii gipoksicheskoj i ortostaticheskoj nagruzok. Vestnik Rossijskoj voenno-medicinskoj akademii. 2015; 1 (49): 57–63. Russian.
  35. Meerson FZ. Mehanizmy fenotipicheskoj adaptacii i principy ee ispol'zovanija dlja preduprezhdenija serdechno-sosudistyh narushenij. Kardiologija. 1978; 18 (10): 18–29. Russian.
  36. Bernardi L, Passino C, Serebrovskaya Z, Serebrovskaya T, Appenzeller O. Respiratory and cardiovascular adaptations to progressive hypoxia. Effect of interval hypoxic training. European Heart Journal. 2001; 22 (10): 879–86.
  37. Jelkmann W. Regulation of erythropoietin production. The Journal of Physiology. 2011; 589 (6): 1251–8.
  38. Hahn AG, Gore CJ. The effect of altitude on cycling performance: a challenge to traditional concepts. Sports Medicine. 2001; 31: 533–57.
  39. Soliz J, Soulage C, Hermann DM, Gassmann M. Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2007; 293: R1702–10.
  40. Sasaki R, Masuda S, Nagao M. Erythropoietin: multiple physiological functions and regulations of biosynthesis. Bioscience, Biotechnology, and Biochemistry. 2000; 64: 1775–93.
  41. Kolesnikova EYe, Garmatina OYu, Drevickaya TI. Jekspressija mRNK jeritropojetina v stvole mozga krys pri adaptacii k interval'noj gipoksii. Nejrofiziologija. 2009; 41 (3): 226–30. Russian.
  42. Grover RF, Bartsch P. Blood. In: Hornbein TF, Schoene RD, editors. High altitude. An Exploration of human adaption. New York: Dekar, 2001; р. 493–523.
  43. Holliss BA, Fulford J, Vanhatalo A, Pedral CR, Jones AM. Influence of intermittent hypoxic training on muscle energetic and exercise. Journal of Appl Physiol. 2013; 114: 611–19.
  44. Levine BD. Intermittent hypoxic training: Fact and fancy. High Altitude Medicine & Biology. 2002; 3 (2): 177–93.
  45. Kolchinskaya AZ. Interval'naja gipoksicheskaja trenirovka v sporte vysshih dostizhenij. Sportivnaja medicina. 2008; 1: 9–25. Russian.
  46. Core CJ, Clark SA, Saunders PU. Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Medicine & Science in Sports & Exercise. 2007; 39 (9): 1600–9.
  47. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molecular and Cellular Biology. 1992; 12 (12): 5447–54.
  48. Semenza GL. O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. Journal of Appl Physiol. 2004; 96: 1173–7.