Mechanisms of B lymphocyte involvement in the pathogenesis of multiple sclerosis

Melnikov MV1,2,3, Rogovskii VS1,2, Lopatina AV1,2, Sviridova AA1,2, Volkov AI1, Boyko AN1,2
About authors

1 Federal Center for Brain Research and Neurotechnologies of FMBA, Moscow, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

3 Institute of Immunology of Federal Medical-Biological Agency, Moscow, Russia

Correspondence should be addressed: Mikhail V. Melnikov
Ostrovitianova, 1, Moscow, 117997; ur.xednay@smkidem

About paper

Author contribution: Melnikov MV — manuscript writing and editing; Rogovskii VS, Lopatina AV, Volkov AI — manuscript writing; Sviridova AA — manuscript writing and formatting; Boyko AN — study concept and design, manuscript editing

Received: 2021-07-17 Accepted: 2021-08-06 Published online: 2021-08-16

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system involving autoimmune mechanisms. MS has been treated as a disorder mediated mainly by T cells for a long time. However, recent findings demonstrate that B lymphocytes are of crucial pathogenetic significance in MS. In patients with MS, B cells can possess both pro-inflammatory and anti-inflammatory effects. The paper reports the main mechanisms of B lymphocyte involvement in the pathogenesis of MS. Diagnostic value of assessing humoral immune parameters in individuals with demyelinating diseases and modern possibility of B cell function modulation are discussed.