ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
Copyright: © 2021 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Evaluation of avian adenovirus inactivation methods used in the production of influenza vaccines
About authors
1 Saint Petersburg Research Institute of Vaccines and Serums, FMBA, Russia
2 Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, Russia
Correspondence should be addressed: Natalya N. Savina
Svobody, 52, Krasnoye Selo, Saint Petersburg, 198320; ur.sviinbps@anivas.n.n
About paper
Author contribution: all authors have equally contributed to the methodology of the study, analysis and interpretation of the results and manuscript preparation.
Compliance with ethical standards: the study complied with the principles of the Declaration of Helsinki (1964) and its revisions.
Received: 2021-08-18
Accepted: 2021-09-12
Published online: 2021-09-26
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Fig. 1. Dynamics of CELO and Fontes inactivation in the presence of β-propiolactone
Fig. 2. Dynamics of CELO and Fontes inactivation by UV light
Fig. 3. Dynamics of CELO and Fontes inactivation by n-octyl-β-D-glucopyranoside
Fig. 4. Dynamics of CELO and Fontes inactivation by tetradecyltrimethylammonium bromide
Table 1. Infectious titers of CELO and Fontes adenoviruses cultured in different cell lines
Table 2. A reduction in adenovirus titers following exposure to different inactivating agents
