Evaluation of avian adenovirus inactivation methods used in the production of influenza vaccines

About authors

1 Saint Petersburg Research Institute of Vaccines and Serums, FMBA, Russia

2 Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, Russia

Correspondence should be addressed: Natalya N. Savina
Svobody, 52, Krasnoye Selo, Saint Petersburg, 198320; ur.sviinbps@anivas.n.n

About paper

Author contribution: all authors have equally contributed to the methodology of the study, analysis and interpretation of the results and manuscript preparation.

Compliance with ethical standards: the study complied with the principles of the Declaration of Helsinki (1964) and its revisions.

Received: 2021-08-18 Accepted: 2021-09-12 Published online: 2021-09-26
Fig. 1. Dynamics of CELO and Fontes inactivation in the presence of β-propiolactone
Fig. 2. Dynamics of CELO and Fontes inactivation by UV light
Fig. 3. Dynamics of CELO and Fontes inactivation by n-octyl-β-D-glucopyranoside
Fig. 4. Dynamics of CELO and Fontes inactivation by tetradecyltrimethylammonium bromide
Table 1. Infectious titers of CELO and Fontes adenoviruses cultured in different cell lines
Table 2. A reduction in adenovirus titers following exposure to different inactivating agents