ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Peripheral blood hematopoietic stem cell pool in individuals chronically exposed to radiation over a long-term period
About authors
1 Ural Research Center for Radiation Medicine, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
Correspondence should be addressed: Alisa I. Kotikova
Vorovskogo, 68, korp. А, Chelyabinsk, Russia, 454141; moc.liamg@asilaavokitok
About paper
Funding: the study was carried out within the framework of the State assignment “Human Cell-Mediated Immunity During Realization of Chronic Radiation Exposure Late Effects” (code 27.002.20.800).
Author contribution: Kotikova AI — method design, laboratory tests, statistical analysis, manuscript writing; Blinova ЕА — method design, manuscript writing; Akleyev AV — study concept, scientific management.
Compliance with ethical standards: the study was approved by the Ethics Committee of Urals Research Center for Radiation Medicine (protocol № 3 dated July 20, 2021). All the subjects enrolled in the studies conducted by Laboratory of Molecular and Cellular Radiobiology of Urals Research Center for Radiation Medicine submitted the informed consent.
Received: 2021-07-21
Accepted: 2021-08-10
Published online: 2021-09-03
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Fig. Correlation of peripheral blood CD34+ cell counts with age in individuals of joint comparison group
Table 1. Characteristics of the studied population
Note: *n — studied population size; **M ± SE — mean ± standard error of the mean; *** — significance level for intergroup differences in etnicity; **** — significance level for intergroup differences in gender; ***** — significance level for intergroup differences in age.
Table 2. Levels of CD34+ cells in peripheral blood of the subjects
Note: Me — median; p1 — significance level for differences in absolute CD34+ cell counts in the groups of individuals born in 1950–1960; p2 — significance level for differences in relative CD34+ cell counts in the groups of individuals born in 1950–1960; p3 — significance level for differences in absolute CD34+ cell counts in the groups of individuals born until 1949 inclusive; p4 — significance level for differences in relative CD34+ cell counts in the groups of individuals born until 1949 inclusive.
