ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
REVIEW
Cardiovascular comorbidity in patients with nonalcoholic fatty liver disease
About authors
1 Volgograd Medical Clinical Center of FMBA, Volgograd, Russia
2 Volgograd State Medical University, Volgograd, Russia
Correspondence should be addressed: Elena E. Gorbacheva
Kim, d. 24, k. 125, Volgograd, 400001, Russia; ur.xednay@1ilsak
About paper
Author contribution: Ledovskaya TI — conceived the idea, performed data analysis and interpretation; Statsenko ME, Turkina SV — formulated the problem and organized the study; Konyakhina TA — performed literature analysis and research conceptualization; Yusupov KS — searched the literature and wrote the manuscript; Gorbacheva EE — performed data analysis and interpretation.
Received: 2021-12-07
Accepted: 2021-12-20
Published online: 2021-12-22
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Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It is characterized by hepatic steatosis and stetohepatitis and in some cases can progress to cirrhosis with or without hepatic failure and hepatocellular carcinoma. At present, NAFLD is deemed a predictor of cardiovascular risk. Besides, it can aggravate pre-existing cardiovascular conditions. Structural and functional changes in the heart, liver and blood vessels are interdependent and mutually aggravating. Metabolic factors (dyslipidemia, hyperglycemia and insulin resistance) contribute to hepatic, cardiac and vascular damage, and NAFLD and comorbid cardiovascular disorders together can activate fibrogenesis in the heart, blood vessels and liver.
Keywords: endothelial dysfunction, nonalcoholic fatty liver disease, fatty steatosis, nonalcoholic steatohepatitis, liver fibrosis