OPINION

The component of pathogenesis of sudden nocturnal death in patients with heart failure

About authors

Federal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological Agency, Center for Syncope and Cardiac Arrhythmias, Moscow, Russia

Correspondence should be addressed: Leonid M. Makarov
Moskvorechye, 20, Moscow, 115409, Russia; ur.liam@vorakamdinoel.rd

Received: 2022-07-06 Accepted: 2022-07-23 Published online: 2022-08-09
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Fig. 1. Assessment of the 24-hr QT dynamics in healthy male aged 22 using the modern Holter monitoring system. QT/RR slope (QTо) = 0.199
Fig. 2. Ventricular tachyarrhythmia that occurs at 05:44 am, ventricular fibrillation and sudden death that occur at 05:56 am in female patient aged 77 with ischemic cardiomyopathy and ejection fraction of 38%. No option for assessment of QT dynamics was installed in the system
Fig. 3. Nocturnal heart rate trend with sudden death occurring at 05:56 am (see Fig. 1) during the period of the increased heart rate variability that corresponds to REM sleep phase according to conventional somnography [8, 13] in the 77-year old female patient with ischemic cardiomyopathy
Fig. 4. QT hyperadaptation in male patient with type 3 long QT syndrome. QT/RR slope (QTо) = 0.369 (normal range: 0.13–0.24)