ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
REVIEW
Methodological aspects of drug development and preclinical research in the interests of Artic medicine
About authors
Moscow Institute of Physics and Technology (National Research University), Moscow, Russia
Correspondence should be addressed: Marina V. Volkova
Institutsky per., 9, Dolgoprudny, 141701, Russia; ur.tsil@avoklov.hcetoib
About paper
Author contribution: Volkova MV — development of the concept, collection and analysis of the published papers, manuscript authoring; Biryukov SA — manuscript editing.
Compliance with ethical standards: the work was carried out in accordance with the principles of the Declaration of Helsinki.
Received: 2022-12-06
Accepted: 2023-01-25
Published online: 2023-02-26
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Table 1. Methods of modeling hypothermia in rodents
Note: text is ambient temperature; τ is the time of keeping under simulated extreme conditions; N is the number of animals kept simultaneously under simulated conditions (in one cage, if a hermetic chambers was used; group — the exact number of animals in a cage is not given); trect is the rectal temperature of the animals at the end of the keeping period or a limiting value the reaching of which triggered removal of the animal removed from simulated conditions; additional factors list the conditions created while keeping animals in simulated extreme conditions, like immobilization of animals in a plastic case.
Table 2. Simulation of extreme conditions of the Arctic
Note: * — indicates the possibility of conducting tests while maintaining the impact of stress factors on the body. Factor
