Fig. 1. Abdominal organs of the rats deprived of food 48 h before laparotomy: intact (А); 72 h after intravenous injection of cyclophosphamide in a dose of 390 mg/kg (B). Arrows show: 1 — stomach; 2 — caecum

Fig. 2. Relative weight of the gastric (А) and caecal (B) chyme in rats 72 h after intravenous injection of cyclophosphamide in a dose of 390 mg/kg (M ± m; n = 10) depending on the time of access to food after the exposure. Controls — animals not administered with cyclophosphamide. At the beginning of the horizontal axis — values of the group of rats not administered with cyclophosphamide and having unlimited access to food. * — significant differences from controls (p < 0.05)

Fig. 3. Relative weight of the gastric chyme, caecal chyme and the spleen in rats 72 h after intravenous injection of cyclophosphamide in a dose of 390 mg/kg (M ± m; n = 10). “Intact” — rats not administered with drugs; “CP” — rats administered with cyclophosphamide only; “SB + CP” — rats that received intragastric administration of the 4% sodium bicarbonate solution 30 before the cyclophosphamide administration; “SB + CP + SB” — rats that received intragastric administration of the 4% sodium bicarbonate solution 30 before and immediately after the cyclophosphamide administration; “SB + CP + SB”— rats that received intragastric administration of the 4% sodium bicarbonate solution 30 before, immediately after, 1 and 2 h after the cyclophosphamide administration. All the animals were deprived of food 24 h after the cyclophosphamide administration. Significant differences (p < 0.05): * — from the intact group; † — from the “CP” and “NaHCO3 + CP” groups

Fig. 4. Urinary excretion of indican in rats 72 h after intravenous injection of cyclophosphamide in a dose of 390 mg/kg (M ± m; n = 10). The symbols are the same as in Fig. 3

Fig. 5. Annular slices of the duodenum, jejunum, and ileum of the rats 72 h after intravenous injection of cyclophosphamide in a dose of 390 mg/kg