ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Features of using a lymphocyte test for biological dosimetry in the early period after exposure
About authors
Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
Correspondence should be addressed: Mikhail K. Sedankin
Zhivopisnaya, 46, Moscow, 123098, Russia; ur.xednay@niknadesm
About paper
Author contribution: Sedankin MK — study concept and design, manuscript writing, literature review, approval of the final version of the article; Gudkov EA — study concept and design, data acquisition, data interpretation, computation tool development; Soloviev VYu — general management, study concept and design, manuscript writing; Mershin LYu — editing, data interpretation, computation tool optimization.
Received: 2023-08-10
Accepted: 2023-09-11
Published online: 2023-09-28
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Fig. Radiation dose (Gy) as a function of lymphocyte counts (×10^9/L) on day 2 after exposure. Markers indicate baseline data (separately for groups exposed to gamma and gamma neutron radiation), and lines indicate the observed trends
Table 1. Peripheral blood lymphocyte counts (×10^9/L) on day 2 after exposure in victims of the Chernobyl disaster (1986) and other radiation accidents (according to the data from the database on acute radiation injury in humans compiled by the State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency), amended and reworked from the earlier published paper [13]. The cases of exposure to gamma neutron radiation are allocated separately
Table 2. Dose estimation based on the time between blood tests and the ratio of lymphocyte concentrations L2/L1 within 2–18 h after exposure
Table 3. Estimated uncertainty of the received dose (Gy) and radiation injury severity based on peripheral blood lymphocyte concentration on day 2 and the average value on days 3–6 after exposure (based on the data from [9])
