2023 / 04

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DOI: 10.47183/mes.2023.043

ORIGINAL RESEARCH

Familial case of inherited human herpesvirus 6A with phylogenetic assessment

Goleva OV1, Danilov LG2, Kusakin AV1,4, Eismont YuA1, Babachenko IV1, Tian NS1, Chukhlovin AB5, Krylov AV1, Glotov OS1,3,4
About authors

1 Pediatric Research and Clinical Center of Infectious Diseases of the Federal Medical Biological Agency, Saint Petersburg, Russia

2 Saint Petersburg State University, Saint Petersburg, Russia

3 Ott Research Institute of Obstetrics and Gynecology, Saint Petersburg, Russia

4 ITMO University, Saint Petersburg, Russia

5 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia

Correspondence should be addressed: Olga V. Goleva
Professor Popov, 9, Saint Petersburg, 197022, Russia;

About paper

Author contribution: Goleva OV, Babachenko IV, Tian NS — study planning, data acquisition, analysis and interpretation, manuscript draft; Danilov LG — bioinformatics analysis, search for analytical papers; Kusakin AV — study planning, literature review, data acquisition, analysis and interpretation, bioinformatics analysis, constructing a phylogenetic tree, manuscript draft; Eismont YuA, Chukhlovin AB — study planning, data acquisition, analysis and interpretation; Krylov AV — data acquisition, analysis and interpretation; Glotov OS — research supervision, data analysis and interpretation, manuscript draft.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Pediatric Research and Clinical Center for Infectious Diseases of FMBA of Russia (protocol № 107 dated November 27, 2018) and conducted in accordance with the latest edition of the Declaration of Helsinki. Patients and their legal representatives submitted the informed consent to the study participation.

Received: 2023-08-18 Accepted: 2023-09-19 Published online: 2023-10-26
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Fig. Phylogenetic position of novel type 6 herpesvirus relative to other herpes strains based on gene gB: position of new virus is highlighted in red in the tree, two viral strains from Moscow are highlighted in blue
Table 1. Laboratory markers of herpesvirus infections at admission
Note: * — gEq/mL; * * — AU.
Table 2. Laboratory markers of herpesvirus infections obtained during re-examination eight months later
Note: * — gEq/mL; * * — AU.
Table 3. Laboratory markers of herpesvirus infection in other family members
Note: * — gEq/mL.