ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Association of GSTP1 gene with renal function in patients with diabetes mellitus
About authors
1 Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical Biological Agency, Moscow, Russia
2 Federal Research and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical Biological Agency, Moscow, Russia
Correspondence should be addressed: Nadezhda Ya. Kostyushok
Sedina, 4, Krasnodar, 350063, Russia; ur.tsil@NavolagahS
About paper
Author contribution: Kostyushok NYa — preparation of tests, experimental procedure, analysis of the results; Gornov SV — research management, manuscript editing; Sizov AV — manuscript revision.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Kuban State Medical University (protocol № 91 dated 29 September 2020). All patients submitted the informed consent to study participation.
Received: 2024-01-25
Accepted: 2024-03-15
Published online: 2024-03-28
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Table 1. Comparison of the GSTP1 (I105V) allele frequencies in the studied groups
Table 2. Features of changes in the lipid profile indicators and glycated hemoglobin levels in patients with type 1 DM having various GSTP1 (I105V) allele variants
Note: * — differences between the group of patients with type 1 DM having the gene polymorphism in the heterozygous state and the patients with type 1 DM having the gene polymorphism in the homozygous state (homozygote for allele 1) at p < 0.05 (* * — p < 0.01, * * * — p < 0.001).
Table 3. Indicators of the antioxidant defense system and lipid peroxidation in individuals with various GSTP1 (Ile105Val) polymorphic variants
Note: MDA — malondialdehyde; SOD — superoxide dismutase; CAT — catalase; GSТ — glutathione-S-transferase. * — compared to heterozygous carriers of the studied gene in the control group; * * — compared to homozygous carriers of the studied gene in the control group; * * * — compared to the indicators of the index group of genotypes (Ile/Val) and (Ile/Ile). # — differences between the group of patients with type 1 DM having the gene variant in the heterozygous state (Ile/Val) and the patients with type 1 DM having the gene variant in the homozygous state (Ile/Ile) at p < 0.05 (## — p < 0.01; ### — p < 0.001).
