2024 / 01

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DOI: 10.47183/mes.2024.010

CLINICAL CASE

Intracoronary use of levocarnitine for coronary artery stent insertion in high-risk patients

Semigolovskii NYu1,2,3, Balluzek MF1,2, Guslev AB1,2, Mazurenko SO1, Kozaev AV2, Semenova IG2, Nikolskaya EM3, Scheglov AN4
About authors

1 Saint Petersburg State University, Saint Petersburg, Russia

2 Saint Petersburg Clinical Hospital of the Russian Academy of Sciences, Saint Petersburg, Russia

3 Clinical Hospital of the Sokolov North-Western District Scientific and Clinical Center of the Federal Medical Biological Agency, Saint Petersburg, Russia

4 Central Clinical Hospital with a Polyclinic of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia

Correspondence should be addressed: Nikita Yu. Semigolovskii
pr. Kultury, 4, Saint Petersburg, 194291, Russia; ur.xednay@iksvologimes

About paper

Funding: the study was performed as part of the State Assignment No. 075-01609-23-04 “Adjuvant Cytoprotection by Intracoronary Levocarnitine Administration during Revascularization in Patients with Acute and Chronic Coronary Syndrome” (FUEM-2023-0018). Research project No. 1022040701249-2-3.2.4. Agreement No. 075-03-2023-695/1 dated 21.04.2023.

Author contribution: Semigolovskii NYu — study concept and design, text development, literature review; Kozaev AN, Nikolskaya EM, Semenova IG — сollection and processing of material; Mazurenko SO — literature review, material analysis, editing; Guslev AB, Scheglov AN — material analysis; Balluzek MF — material analysis, editing.

Received: 2024-01-29 Accepted: 2024-03-17 Published online: 2024-03-25
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Fig. 1. Dynamic changes in ECG of patient H. aged 76: ECG recorded on 20.09.2023 (before LC administration) is highlighted in green; ECG recorded on 21.09.2023 is highlighted in red, ECG recorded on 25.09.2023 is highlighted in blue; ECG recorded on 26.09.2023 (after LC administration) is highlighted in black
Fig. 2. Angiography of the affected coronary artery of patient H. performed before (on the left) and after (on the right) the stent insertion
Fig. 3. Dynamic changes in ECG of patient L. aged 76: ECG recorded on 25.09.2023 at 10:32, before LC (Elcar) administration, is highlighted in black; ECG recorded on 25.09.2023 at 18:52, after LC (Elcar) administration, is highlighted in red; ECG recorded on 26.09.2023 is highlighted in green; ECG recorded on 29.09.2023 is highlighted in pink
Fig. 4. Angiography of the affected coronary artery of patient L. performed before (on the left) and after (on the right) the stent insertion
Table 1. Dynamic changes in the levels of myocardial ischemia/necrosis biomarkers in patient H.
Note: ALT — alanine aminotransferase, AST — aspartate aminotransferase, CPK — creatine phosphokinase, CPK-MB — creatine phosphokinase-MB.
Table 2. Dynamic changes in the levels of myocardial ischemia/necrosis biomarkers in patient L.
Note: ALT — alanine aminotransferase, AST — aspartate aminotransferase, CPK — creatine phosphokinase, CPK-MB — creatine phosphokinase-MB.