ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
REVIEW
Morphological characteristics of toxic brain damage
About authors
1 Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency, Saint-Petersburg, Russia
2 Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint-Petersburg, Russia
Correspondence should be addressed: Elena D. Bazhanova
Bekhtereva, 1, Saint-Petersburg, Russia; 192019; ur.liam@eavonahzab
About paper
Funding: the study was conducted as part of the State Assignment of the FMBA of Russia No. 388-00071-24-00 (theme code 64.004.24.800) and supported by the State Assignment of the Sechenov Institute of Evolutionary Physiology and Biochemistry RAS No. 075-00264-24-00.
Author contribution: Gaikova ON, Sokolova YuO, Bazhanova ED, Kozlov AA – literature review, data acquisition and processing, manuscript writing and editing; Katretskaya GG, Melnikova MV, Melekhova AS, Bondarenko AA – editing, formatting, approval of the final version of the article.
Received: 2024-05-15
Accepted: 2024-06-17
Published online: 2024-06-28
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The effects of various toxicants on the body tissues cause tissue abnormalities resulting in dystrophic changes and necrosis. The nervous system is the most vulnerable to the effects of exogenic substances, both chemical and biological, due to high metabolic activity and the cells' incapability of self-renewal. Neurotoxicants lead to disturbances of cellular nutrition and eventually to neurodegeneration. Neurons can die due to both apoptosis and necrosis.
Keywords: apoptosis, neurodegeneration, toxic damage, nervous system, dystrophy