ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Changes in some immunological parameters after COVID-19: general trends and individual characteristics
About authors
Russian Hematology and Transfusiology Research Institute of the Federal Medical Biological Agency, St. Petersburg, Russia
Correspondence should be addressed: Tatyana Valentinovna Glazanova
2-ya Sovetskaya, 16, St. Petersburg, 191023, Russia; ur.xednay@avonazalg-anaytat
About paper
Compliance with the ethical standards: the study was approved by the Ethics Committee of the Russian Hematology and Transfusiology Research Institute of the FMBA of Russia (Minutes #31 of July 20, 2023). All participants have voluntarily signed informed consent forms.
Received: 2024-04-02
Accepted: 2024-06-08
Published online: 2024-06-30
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Fig. Immunophenotypic study results, patient A. Device used for the study: Navios EX 10 Colors (Beckman Coulter; USA). The lymphocytic pool was isolated by the parameters of direct and lateral light scattering with CD45 gating. A, B. Results of the study of August 2021. For these histograms, a 5 color panel was used: 1) CD20–FITC+CD23–PE+CD45–ECD+CD19–Pc5+CD5–Pc7 and 2) CD22–FITC+CD43-PE+CD19–Pc5+CD45–Pc7. C, D. Results of the study of April 2023. For these histograms, a 10 color panel was used: FMC7–FITC+CD23–PE+CD19–ECD+CD79b–Pc5.5+CD200–Pc7+CD43–A750+CD38–A700+IgM–PB+CD45–KO. X-axis: CD19+ (%), Y-axis: A and C — CD43+ (%), B and D — CD23+ (%). The upper right quadrants of all the histograms (C2 (A), E2 (B), L2(C) and B2 (D)) show the region where the clone of pathological cells characteristic of B-CLL should be located
Table 1. Post-COVID cellular immunity indicators, groups by disease course severity
Table 2. Post-COVID abnormalities in the CD3+ and CD19+ counts (peripheral blood), % of the examined
Table 3. Content of CIC in COVID-19 patients, depending on the severity of the disease
Table 4. Frequency of occurrence of certain symptoms in COVID-19 survivors depending on the level of CIClow
