ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
The impact of polymorphisms in antioxidant genes on the risk of malignant neoplasm development in exposed individuals
About authors
Urals Research Center for Radiation Medicine of the Federal Medical Biological Agency, Chelyabinsk, Russia
Correspondence should be addressed: Eugenia A. Blinova
Vorovsky, 68-А, Chelyabinsk, 454141, Russia; ur.mrcru@avonilb
About paper
Funding: the paper was prepared during implementation of a part of the research project (contract No. 635/FMBC/23 dated 29.11.2023).
Author contributions: Blinova EA — developing the method, manuscript writing; Korechenkova AV — statistical data processing, manuscript writing; Yanishevskaya MA — laboratory tests, manuscript writing; Akleyev AV — study conception and design, manuscript writing, academic advising.
Compliance with ethical standards: all the subjects submitted the form of the informed consent to study participation and biomaterial sampling and storage in the tissue bank finalized in the study protocol approved by the Ethics Committee of the Urals Research Center for Radiation Medicine of FMBA of Russia (protocol No. 2 dated 13 April 2023) before inclusion in the study.
Received: 2024-03-25
Accepted: 2024-06-03
Published online: 2024-06-26
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Fig. 1. Distribution of MNs in the group of exposed individuals depending on the cancer localization
Fig. 2. Graph of interaction between the elements of the 3-factor model
Table 1. Characteristics of the studied groups
Note: mean ± SD (min–max) — mean ± standard deviation (min–max); mean ± SE (min–max) — mean ± standard error of the mean (min–max).
Table 2. Characteristics of polymorphic regions
Note: 2KB Upstream Variant — a sequence variant located within 2KB 5' of a gene.
Table 3. Abundance of the studied SNP genotypes in exposed individuals
Note: Ho — observed heterozygosity; He — expected heterozygosity; p — value for the Hardy–Weinberg test.
Table 4. Association of SNPs with the risk of MN development
Note: OR (95% CI) — odds ratio with the 95% confidence interval.
Table 5. Models of intergenic interactions with the accumulated dose in chronically exposed individuals
Note: р — value for the testing balanced accuracy obtained in the 1000-fold permutation test; Se — sensitivity; Sp — specificity.
