REVIEW

Role of heredity, endogenous and exogenous factors in gastric cancer

Ershov PV, Veselovsky EM, Konstantinova YuS
About authors

Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia

Correspondence should be addressed: Pavel V. Ershov
Pogodinskaya, 10, str. 1, Moscow, 119121; ur.xobni@97levap

About paper

Author contribution: Ershov PV performed literature search and wrote the draft of the manuscript; Veselovsky EM performed literature search, wrote the Genetic factors for GC risk section and edited the manuscript; Konstantinova YuS performed literature search, proposed the concept of the study and edited the manuscript.

Received: 2020-10-26 Accepted: 2020-11-25 Published online: 2020-12-19
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  1. Ang TL, Fock KM. Clinical epidemiology of gastric cancer. Singapore Med J. 2014; 55 (12): 621–8. DOI: 10.11622/smedj.2014174.
  2. Marqués-Lespier JM, González-Pons M, Cruz-Correa M. Current Perspectives on Gastric Cancer. Gastroenterol Clin North Am. 2016; 45 (3): 413–28. DOI: 10.1016/j.gtc.2016.04.002.
  3. Isobe Y, Nashimoto A, Akazawa K, et al. Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry. Gastric Cancer. 2011; 14 (4): 301–16. DOI: 10.1007/s10120- 011-0085-6.
  4. Cai L, Zheng ZL, Zhang ZF. Risk factors for the gastric cardia cancer: a case-control study in Fujian Province. World J Gastroenterol. 2003; 9 (2): 214–8. DOI: 10.3748/wjg.v9.i2.214.
  5. Zamani N, Hajifaraji M, Fazel-tabar Malekshah A, Keshtkar AA, Esmaillzadeh A, Malekzadeh R. A case-control study of the relationship between gastric cancer and meat consumption in Iran. Arch Iran Med. 2013; 16 (6): 324–9.
  6. Campos F, Carrasquilla G, Koriyama C, et al. Risk factors of gastric cancer specific for tumor location and histology in Cali, Colombia. World J Gastroenterol. 2006; 12 (36): 5772–9. DOI: 10.3748/wjg.v12.i36.5772.
  7. Ferguson LR. Meat and cancer. Meat Sci. 2010; 84 (2): 308–13. DOI: 10.1016/j.meatsci.2009.06.032
  8. Carr PR, Walter V, Brenner H, Hoffmeister M. Meat subtypes and their association with colorectal cancer: Systematic review and meta-analysis. Int J Cancer. 2016; 138 (2): 293–302. DOI: 10.1002/ijc.29423.
  9. Fang X, Wei J, He X, et al. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. Eur J Cancer. 2015; 51 (18): 2820–32. DOI: 10.1016/j.ejca.2015.09.010.
  10. Hu J, La Vecchia C, de Groh M, et al. Dietary cholesterol intake and cancer. Ann Oncol. 2012; 23 (2): 491–500. DOI: 10.1093/ annonc/mdr155.
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr. 2012; 31 (4): 489–98. DOI: 10.1016/j.clnu.2012.01.003.
  12. Peleteiro B, Lopes C, Figueiredo C, Lunet N. Salt intake and gastric cancer risk according to Helicobacter pylori infection, smoking, tumour site and histological type. Br J Cancer. 2011; 104 (1): 198–207. DOI: 10.1038/sj.bjc.6605993.
  13. Parkin DM. 7. Cancers attributable to dietary factors in the UK in 2010. IV. Salt. Br J Cancer. 2011; 105 Suppl 2 (Suppl 2): S31– S33. DOI: 10.1038/bjc.2011.480.
  14. Ren JS, Kamangar F, Forman D, Islami F. Pickled food and risk of gastric cancer--a systematic review and meta-analysis of English and Chinese literature. Cancer Epidemiol Biomarkers Prev. 2012; 21 (6): 905–15. DOI: 10.1158/1055-9965.EPI-12-0202.
  15. Cai L, Zheng ZL, Zhang ZF. Risk factors for the gastric cardia cancer: a case-control study in Fujian Province. World J Gastroenterol. 2003; 9 (2): 214–8. DOI: 10.3748/wjg.v9.i2.214.
  16. Joossens JV, Hill MJ, Elliott P, et al. Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol. 1996; 25 (3): 494–504. DOI: 10.1093/ ije/25.3.494.
  17. Suwanrungruang K, Sriamporn S, Wiangnon S, et al. Lifestyle-related risk factors for stomach cancer in northeast Thailand. Asian Pac J Cancer Prev. 2008; 9 (1): 71–75.
  18. Colomer R, Menéndez JA. Mediterranean diet, olive oil and cancer. Clin Transl Oncol. 2006; 8 (1): 15–21. DOI: 10.1007/ s12094-006-0090-0.
  19. Laake I, Carlsen MH, Pedersen JI, et al. Intake of trans fatty acids from partially hydrogenated vegetable and fish oils and ruminant fat in relation to cancer risk. Int J Cancer. 2013; 132 (6): 1389– 1403. DOI: 10.1002/ijc.27737.
  20. Xie Y, Huang S, He T, Su Y. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Asia Pac J Clin Nutr. 2016; 25 (3): 578–88. DOI: 10.6133/apjcn.092015.07.
  21. Shen Z, Liu H, Cao H. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Clin Res Hepatol Gastroenterol. 2015; 39 (2): 245–53. DOI: 10.1016/j.clinre.2014.09.005.
  22. Gao Y, Hu N, Han XY, et al. Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study. Cancer Epidemiol. 2011; 35 (6): e91–e99. DOI: 10.1016/j. canep.2011.06.006.
  23. Nemati A, Mahdavi R, Naghizadeh Baghi A. Case-control study of dietary pattern and other risk factors for gastric cancer. Health Promot Perspect. 2012; 2 (1): 20–27. DOI: 10.5681/ hpp.2012.003.
  24. Sieri S, Agnoli C, Pala V, et al. Dietary glycemic index, glycemic load, and cancer risk: results from the EPIC-Italy study. Sci Rep. 2017; 7 (1): 9757. DOI: 10.1038/s41598-017-09498-2.
  25. Ladeiras-Lopes R, Pereira AK, Nogueira A, et al. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008; 19 (7): 689–701. DOI: 10.1007/s10552-008-9132-y.
  26. Wang PL, Xiao FT, Gong BC, Liu FN. Alcohol drinking and gastric cancer risk: a meta-analysis of observational studies. Oncotarget. 2017; 8 (58): 99013–23. DOI: 10.18632/oncotarget.20918.
  27. Everatt R, Tamosiunas A, Kuzmickiene I, et al. Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up. BMC Cancer. 2012; 12: 475. Published 2012 Oct 15. DOI: 10.1186/1471-2407-12-475.
  28. Duell EJ, Travier N, Lujan-Barroso L, et al. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr. 2011; 94 (5): 1266–75. DOI: 10.3945/ajcn.111.012351.
  29. Rauf A, Imran M, Butt MS, Nadeem M, Peters DG, Mubarak MS. Resveratrol as an anti-cancer agent: A review. Crit Rev Food Sci Nutr. 2018; 58 (9): 1428–47. DOI: 10.1080/10408398.2016.1263597.
  30. Malekzadeh MM, Khademi H, Pourshams A, et al. Opium use and risk of mortality from digestive diseases: a prospective cohort study. Am J Gastroenterol. 2013; 108 (11): 1757–65. DOI: 10.1038/ajg.2013.336.
  31. Shakeri R, Malekzadeh R, Etemadi A, et al. Opium: an emerging risk factor for gastric adenocarcinoma. Int J Cancer. 2013; 133 (2): 455–61. DOI: 10.1002/ijc.28018.
  32. Chen Y, Tan F, Wei L, et al. Sleep duration and the risk of cancer: a systematic review and meta-analysis including dose-response relationship. BMC Cancer. 2018; 18 (1): 1149. DOI: 10.1186/ s12885-018-5025-y.
  33. Gu F, Xiao Q, Chu LW, et al. Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort. PLoS One. 2016; 11 (9): e0161561. DOI: 10.1371/journal.pone.0161561.
  34. Chen Y, Tan F, Wei L, et al. Sleep duration and the risk of cancer: a systematic review and meta-analysis including dose-response relationship. BMC Cancer. 2018; 18 (1): 1149. DOI: 10.1186/ s12885-018-5025-y.
  35. Herszényi L, Juhász M, Mihály E, Tulassay Z. A fekélybetegség és a stressz [Peptic ulcer disease and stress]. Orv Hetil. 2015; 156 (35): 1426–9. DOI: 10.1556/650.2015.30249.
  36. Hardbower DM, de Sablet T, Chaturvedi R, Wilson KT. Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer? Gut Microbes. 2013; 4 (6): 475–81. DOI: 10.4161/gmic.25583.
  37. Zhang X, Zhang Y, He Z, et al. Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2. Cell Death Dis. 2019; 10 (11): 788. DOI: 10.1038/s41419-019- 2030-2.
  38. Xie SH, Chen R, Zhao DL, et al. Status of non-steroidal anti-inflammatory drugs use in areas with a high incidence of upper gastrointestinal cancer in China: a multi-center cross-sectional survey. Zhonghua Yu Fang Yi Xue Za Zhi. 2019; 53 (11): 1098– 103. DOI: 10.3760/cma.j.issn.0253-9624.2019.11.005.
  39. Dai Y, Wang WH. Non-steroidal anti-inflammatory drugs in prevention of gastric cancer. World J Gastroenterol. 2006; 12 (18): 2884–9. DOI: 10.3748/wjg.v12.i18.2884.
  40. Farrow DC, Vaughan TL, Hansten PD, et al. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev. 1998; 7 (2): 97–102.
  41. Zaleska M, Mozenska O, Bil J. Statins use and cancer: an update. Future Oncol. 2018; 14 (15): 1497–509. DOI: 10.2217/fon-2017- 0543.
  42. Wu XD, Zeng K, Xue FQ, Chen JH, Chen YQ. Statins are associated with reduced risk of gastric cancer: a meta-analysis. Eur J Clin Pharmacol. 2013; 69 (10): 1855–60. DOI: 10.1007/ s00228-013-1547-z.
  43. Wu AH, Tseng CC, Bernstein L. Hiatal hernia, reflux symptoms, body size, and risk of esophageal and gastric adenocarcinoma. Cancer. 2003; 98 (5): 940–8. DOI: 10.1002/cncr.11568.
  44. Derakhshan MH, Malekzadeh R, Watabe H, et al. Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut. 2008; 57 (3): 298–305. DOI: 10.1136/gut.2007.137364.
  45. Hansen S, Vollset SE, Derakhshan MH, et al. Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut. 2007; 56 (7): 918–25. DOI: 10.1136/gut.2006.114504.
  46. Li F, Du H, Li S, Liu J. The Association Between Metabolic Syndrome and Gastric Cancer in Chinese. Front Oncol. 2018; 8: 326. Published 2018 Aug 23. DOI: 10.3389/fonc.2018.00326.
  47. Abudawood M. Diabetes and cancer: A comprehensive review. J Res Med Sci. 2019; 24: 94. DOI: 10.4103/jrms.JRMS_242_19.
  48. Miao ZF, Xu H, Xu YY, et al. Diabetes mellitus and the risk of gastric cancer: a meta-analysis of cohort studies. Oncotarget. 2017; 8 (27): 44881–92. DOI: 10.18632/oncotarget.16487.
  49. Kwon HJ, Park MI, Park SJ, et al. Insulin Resistance Is Associated with Early Gastric Cancer: A Prospective Multicenter Case Control Study. Gut Liver. 2019; 13 (2): 154–60. DOI: 10.5009/gnl17556.
  50. Ikeda F, DOI Y, Yonemoto K, et al. Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection: a population-based cohort study. Gastroenterology. 2009; 136 (4): 1234–41. DOI: 10.1053/j.gastro.2008.12.045.
  51. Cheung KS, Chan EW, Chen L, Seto WK, Wong ICK, Leung WK. Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis. Diabetes Care. 2019; 42 (9): 1769–75. DOI: 10.2337/ dc19-0437.
  52. Huang YK, Kang WM, Ma ZQ, Liu YQ, Zhou L, Yu JC. Body mass index, serum total cholesterol, and risk of gastric high-grade dysplasia: A case-control study among Chinese adults. Medicine (Baltimore). 2016; 95 (35): e4730. DOI: 10.1097/ MD.0000000000004730.
  53. Kim HY. Metabolic syndrome is associated with gastric dysplasia. Eur J Gastroenterol Hepatol. 2011; 23 (10): 871–5. DOI: 10.1097/ MEG.0b013e328349aa18.
  54. Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism. 2019; 92: 121–35. DOI: 10.1016/j. metabol.2018.11.001.
  55. Garai J, Uddo RB, Mohler MC, et al. At the crossroad between obesity and gastric cancer. Methods Mol Biol. 2015; 1238: 689– 707. DOI: 10.1007/978-1-4939-1804-1_36.
  56. Li Q, Zhang J, Zhou Y, Qiao L. Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012; 17: 2383–90. DOI: 10.2741/4059.
  57. Du X, Hidayat K, Shi BM. Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies. Biosci Rep. 2017; 37 (3): BSR20160474. Published 2017 May 11. DOI: 10.1042/BSR20160474.
  58. Song M, Latorre G, Ivanovic-Zuvic D, Camargo MC, Rabkin CS. Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis. Cancer Res Treat. 2019; 51 (3): 841– 50. DOI: 10.4143/crt.2019.151.
  59. Suzuki H, Iwasaki E, Hibi T. Helicobacter pylori and gastric cancer. Gastric Cancer. 2009; 12 (2): 79–87. DOI: 10.1007/s10120-009- 0507-x.
  60. Lee SA, Kang D, Shim KN, Choe JW, Hong WS, Choi H. Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer. J Epidemiol. 2003; 13 (3): 162–8. DOI: 10.2188/jea.13.162.
  61. Sheu MJ, Yang HB, Sheu BS, Cheng HC, Lin CY, Wu JJ. Erythrocyte Lewis (A+B-) host phenotype is a factor with familial clustering for increased risk of Helicobacter pylori-related non-cardiac gastric cancer. J Gastroenterol Hepatol. 2006; 21 (6): 1054–8. DOI: 10.1111/j.1440-1746.2005.04050.x.
  62. Lee YC, Chiang TH, Chou CK, et al. Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis. Gastroenterology. 2016; 150 (5): 1113–24. DOI: 10.1053/j.gastro.2016.01.028.
  63. Zeng ZM, Luo FF, Zou LX, et al. Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases. Onco Targets Ther. 2016; 9: 7105–14. DOI: 10.2147/OTT. S115053.
  64. Coghill AE, Hildesheim A. Epstein-Barr virus antibodies and the risk of associated malignancies: review of the literature. Am J Epidemiol. 2014; 180 (7): 687–95. DOI: 10.1093/aje/kwu176.
  65. Koshiol J, Qiao YL, Mark SD, et al. Epstein–Barr virus serology and gastric cancer incidence and survival. Br J Cancer. 2007; 97 (11): 1567–9. DOI: 10.1038/sj.bjc.6604063.
  66. Levine PH, Stemmermann G, Lennette ET, Hildesheim A, Shibata D, Nomura A. Elevated antibody titers to Epstein–Barr virus prior to the diagnosis of Epstein–Barr-virus-associated gastric adenocarcinoma. Int J Cancer. 1995; 60 (5): 642–4. DOI: 10.1002/ijc.2910600513.
  67. de Souza CRT, Almeida MCA, Khayat AS, et al. Association between Helicobacter pylori, Epstein–Barr virus, human papillomavirus and gastric adenocarcinomas. World J Gastroenterol. 2018; 24 (43): 4928–38. DOI: 10.3748/wjg.v24.i43.4928.
  68. Zou L, Luo K, Qiao O, Xu J. Global gene expression responses to Iodine-125 radiation in three human gastric cancer cell lines. Zhonghua Wai Ke Za Zhi. 2014; 52 (8): 612–6.
  69. Hauptmann M, Fossa SD, Stovall M, et al. Increased stomach cancer risk following radiotherapy for testicular cancer. Br J Cancer. 2015; 112 (1): 44–51. DOI: 10.1038/bjc.2014.552.
  70. Nandakumar A, Uwatoko F, Yamamoto M, et al. Radiation-induced Epstein–Barr virus reactivation in gastric cancer cells with latent EBV infection. Tumour Biol. 2017; 39 (7): 1010428317717718. DOI: 10.1177/1010428317717718.
  71. Uthman OA, Jadidi E, Moradi T. Socioeconomic position and incidence of gastric cancer: a systematic review and meta-analysis. J Epidemiol Community Health. 2013; 67 (10): 854–60. DOI: 10.1136/jech-2012-201108.
  72. Mendoza D, Herrera P, Gilman RH, et al. Variation in the prevalence of gastric cancer in Perú. Int J Cancer. 2008; 123 (2): 414–20. DOI: 10.1002/ijc.23420.
  73. Rota M, Alicandro G, Pelucchi C, et al. Education and gastric cancer risk-An individual participant data meta-analysis in the StoP project consortium [published correction appears in Int J Cancer. 2020 Jun 1;146(11):E6]. Int J Cancer. 2020; 146 (3): 671–81. DOI: 10.1002/ijc.32298.
  74. Ji J, Hemminki K. Socio-economic and occupational risk factors for gastric cancer: a cohort study in Sweden. Eur J Cancer Prev. 2006; 15 (5): 391–7. DOI: 10.1097/00008469-200610000-00003.
  75. Santibañez M, Alguacil J, de la Hera MG, et al. Occupational exposures and risk of stomach cancer by histological type. Occup Environ Med. 2012; 69 (4): 268–75. DOI: 10.1136/ oemed-2011-100071.
  76. Welling R, Beaumont JJ, Petersen SJ, Alexeeff GV, Steinmaus C. Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence. Occup Environ Med. 2015; 72 (2): 151–9. DOI: 10.1136/oemed-2014-102178.
  77. Choi YJ, Kim N. Gastric cancer and family history. Korean J Intern Med. 2016; 31 (6): 1042–53. DOI: 10.3904/kjim.2016.147.
  78. Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F. Familial gastric cancer: genetic susceptibility, pathology, and implications for management. Lancet Oncol. 2015; 16 (2): e60–e70. DOI: 10.1016/S1470-2045(14)71016-2.
  79. Yaghoobi M, Bijarchi R, Narod SA. Family history and the risk of gastric cancer. Br J Cancer. 2010; 102 (2): 237–42. DOI: 10.1038/ sj.bjc.6605380.
  80. La Vecchia C, Negri E, Franceschi S, Gentile A. Family history and the risk of stomach and colorectal cancer. Cancer. 1992; 70 (1): 50–55. DOI: 10.1002/1097-0142(19920701)70.
  81. Kokkola A, Sipponen P. Gastric carcinoma in young adults. Hepatogastroenterology. 2001; 48 (42): 1552–1555.
  82. Shin CM, Kim N, Yang HJ, et al. Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. J Clin Gastroenterol. 2010; 44 (2): e34–e39. DOI: 10.1097/ MCG.0b013e3181a159c4.
  83. Brenner H, Arndt V, Stürmer T, Stegmaier C, Ziegler H, Dhom G. Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma. Cancer. 2000; 88 (2): 274–9.
  84. Hansford S, Kaurah P, Li-Chang H, et al. Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond. JAMA Oncol. 2015; 1 (1): 23–32. DOI: 10.1001/jamaoncol.2014.168.
  85. Pharoah PD, Guilford P, Caldas C; International Gastric Cancer Linkage Consortium. Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology. 2001; 121 (6): 1348–53. DOI: 10.1053/gast.2001.29611.
  86. Petrovchich I, Ford JM. Genetic predisposition to gastric cancer. Semin Oncol. 2016; 43 (5): 554–9. DOI: 10.1053/j. seminoncol.2016.08.006.
  87. Hearle N, Schumacher V, Menko FH, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006; 12 (10): 3209–15. DOI: 10.1158/1078-0432.CCR-06- 0083.
  88. Giardiello FM, Brensinger JD, Tersmette AC, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 2000; 119 (6): 1447–53. DOI: 10.1053/gast.2000.20228.
  89. Gupta S, Provenzale D, Llor X, et al. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019. J Natl Compr Canc Netw. 2019; 17 (9): 1032–41. DOI: 10.6004/jnccn.2019.0044.
  90. Jakubowska A, Nej K, Huzarski T, Scott RJ, Lubiński J. BRCA2 gene mutations in families with aggregations of breast and stomach cancers. Br J Cancer. 2002; 87 (8): 888–91. DOI: 10.1038/sj.bjc.6600562.
  91. Moiseyenko VM, Volkov NM, Suspistin EN, et al. Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer. Med Oncol. 2013; 30 (2): 545. DOI: 10.1007/s12032-013-0545-4.
  92. Mayor PC, Eng KH, Singel KL, et al. Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immunol. 2018; 141 (3): 1028–035. DOI: 10.1016/j.jaci.2017.05.024.
  93. Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood. 2012; 119 (7): 1650–7. DOI: 10.1182/ blood-2011-09-377945.
  94. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000; 343 (2): 78–85. DOI: 10.1056/NEJM200007133430201
  95. Tian J, Liu G, Zuo C, Liu C, He W, Chen H. Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies. Cancer Biol Med. 2019; 16 (2): 361–89. DOI: 10.20892/j.issn.2095- 3941.2018.0290.
  96. Setiawan VW, Yu GP, Lu QY, et al. Allium vegetables and stomach cancer risk in China. Asian Pac J Cancer Prev. 2005; 6 (3): 387–95.
  97. Zhou Y, Zhuang W, Hu W, Liu GJ, Wu TX, Wu XT. Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis. Gastroenterology. 2011; 141 (1): 80–89. DOI: 10.1053/j.gastro.2011.03.057.
  98. Fleischauer AT, Poole C, Arab L. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr. 2000; 72 (4): 1047–52. DOI: 10.1093/ajcn/72.4.1047.
  99. Zhang Z, Xu G, Ma M, Yang J, Liu X. Dietary fiber intake reduces risk for gastric cancer: a meta-analysis. Gastroenterology. 2013; 145 (1): 113–20. DOI: 10.1053/j.gastro.2013.04.001.
  100. Hou IC, Amarnani S, Chong MT, Bishayee A. Green tea and the risk of gastric cancer: epidemiological evidence. World J Gastroenterol. 2013; 19 (24): 3713–22. DOI: 10.3748/wjg.v19. i24.3713.
  101. Zhou Y, Wang T, Meng Q, Zhai S. Association of carotenoids with risk of gastric cancer: A meta-analysis. Clin Nutr. 2016; 35 (1): 109–16. DOI: 10.1016/j.clnu.2015.02.003.
  102. Kong P, Cai Q, Geng Q, et al. Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies. PLoS One. 2014; 9 (12): e116060. DOI: 10.1371/journal.pone.0116060.
  103. Ma JL, Zhang L, Brown LM, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012; 104 (6): 488–92. DOI: 10.1093/jnci/djs003.
  104. Mahendra A, Karishma, Choudhury BK, et al. Vitamin D and gastrointestinal cancer. J Lab Physicians. 2018; 10 (1): 1–5. DOI: 10.4103/JLP.JLP_49_17.
  105. Vyas N, Companioni RC, Tiba M, et al. Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis. World J Gastrointest Oncol. 2016; 8 (9): 688–94. DOI: 10.4251/wjgo.v8.i9.688.
  106. Singh K, Gandhi S, Batool R. A Case-Control Study of the Association between Vitamin D Levels and Gastric Incomplete Intestinal Metaplasia. Nutrients. 2018; 10 (5): 629. DOI: 10.3390/ nu10050629.
  107. Kurtzke JF, Hyllested K. Validity of the epidemics of multiple sclerosis in the Faroe Islands. Neuroepidemiology. 1988; 7 (4): 190–227. DOI: 10.1159/000110154.
  108. Gonda TA, Kim YI, Salas MC, et al. Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice. Gastroenterology. 2012; 142 (4): 824–33.e7. DOI: 10.1053/j.gastro.2011.12.058.
  109. Brenner DR, Yannitsos DH, Farris MS, Johansson M, Friedenreich CM. Leisure-time physical activity and lung cancer risk: A systematic review and meta-analysis. Lung Cancer. 2016; 95: 17–27. DOI: 10.1016/j.lungcan.2016.01.021.
  110. de Boer MC, Wörner EA, Verlaan D, van Leeuwen PAM. The Mechanisms and Effects of Physical Activity on Breast Cancer. Clin Breast Cancer. 2017; 17 (4): 272–8. DOI: 10.1016/j. clbc.2017.01.006
  111. Singh S, Edakkanambeth Varayil J, Devanna S, Murad MH, Iyer PG. Physical activity is associated with reduced risk of gastric cancer: a systematic review and meta-analysis. Cancer Prev Res (Phila). 2014; 7 (1): 12–22. DOI: 10.1158/1940-6207.CAPR- 13-0282.
  112. Bae SE, Jung HY, Kang J, et al. Effect of Helicobacter pylori eradication on metachronous recurrence after endoscopic resection of gastric neoplasm. Am J Gastroenterol. 2014; 109 (1): 60–67. DOI: 10.1038/ajg.2013.404.
  113. Hamid RN, Akkurt ZM. Hereditary Tumor Syndromes with Skin Involvement. Dermatol Clin. 2019; 37 (4): 607–13. DOI: 10.1016/j. det.2019.05.016.