2020 / 04

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DOI: 10.47183/mes.2020.022

ORIGINAL RESEARCH

Effect of intermittent hypoxic training on orthostatic tolerance in humans before and after simulated microgravity

Katuntsev VP, Sukhostavtseva TV, Kotov AN, Baranov MV
About authors

Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency, Moscow, Russia

Correspondence should be addressed: Vladimir P. Katuntsev
Dyshinskaya,14, kv. 82, 111024, Moscow; ur.xednay@takpv

About paper

Acknowledgement: the authors thank all volunteers who participated in this study.

Author contribution: Katuntsev VP conceived and designed the study, wrote the manuscript; Sukhostavtseva TV collected and analyzed the obtained data, performed statistical analysis and edited the manuscript; Kotov AN collected and analyzed the obtained data and performed statistical analysis; Baranov MV collected and analyzed the obtained data and edited the manuscript.

Compliance with ethical standards: the study was approved by the Ethics Committee of Federal Research Clinical Center of FMBA (Protocol № 1 dated February 7, 2019) and conformed with the principles of biomedical ethics laid out in the Declaration of Helsinki (the 1964 version and subsequent updates); voluntary informed consent was obtained from each study participant.

Received: 2020-10-07 Accepted: 2020-11-23 Published online: 2020-12-14
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Fig. 1. Effects of 3-day HDBR on cardiovascular responses to the orthostatic test. # (p < 0.05) and ## (p < 0.01) designate differences between the data obtained during OTT and the data obtained from supine subjects before OTT; * (p < 0.05) and ** (p < 0.01) designate differences before and after HDBR
Fig. 2. HR dynamics during the orthostatic test before and after 3 days of HDBR.* (p < 0.05) and ** (p < 0.01) designate differences before and after HDBR
Fig. 3. Effects of 11-day IHT on cardiovascular responses to the orthostatic test before HDBR. # (p < 0.05) and ## (p < 0.01) designate differences between the data obtained during OTT and the data obtained from supine subjects before OTT; * (p < 0.05) marks differences before and after IHT
Fig. 4. Effects of 11-day IHT on cardiovascular responses to the orthostatic test after HDBR. # (p < 0.05) and ## (p < 0.01) designate differences between the data obtained during OTT and the data obtained from supine subjects before OTT; * (p < 0.05) and ** (p < 0.01) designate differences before and after IHT
Fig. 5. Effects of 21-day IHT on cardiovascular responses to the orthostatic test before HDBR. # (p < 0.05) and ## (p < 0.01) designate differences between the data obtained during OTT and before OTT; * (p < 0.01) marks differences before and after HDBR
Рис. 6. Влияние 21-суточного курса ИГТ на ортостатические реакции сердечно-сосудистой системы после АНОГ. # (при p < 0,05) и ## (при p < 0,01) — различия во время ортопробы по сравнению с данными перед ортопробой; * (при p < 0,05) и ** (при p < 0,01) — различия до и после ИГТ
Table. Effects of 3-day HDBR on orthostatic tolerance in subjects
Note: ОTT — orthostatic tilt test; * — p < 0.05.