2020 / 04

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DOI: 10.47183/mes.2020.022

ORIGINAL RESEARCH

Effect of intermittent hypoxic training on orthostatic tolerance in humans before and after simulated microgravity

Katuntsev VP, Sukhostavtseva TV, Kotov AN, Baranov MV
About authors

Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency, Moscow, Russia

Correspondence should be addressed: Vladimir P. Katuntsev
Dyshinskaya,14, kv. 82, 111024, Moscow; ur.xednay@takpv

About paper

Acknowledgement: the authors thank all volunteers who participated in this study.

Author contribution: Katuntsev VP conceived and designed the study, wrote the manuscript; Sukhostavtseva TV collected and analyzed the obtained data, performed statistical analysis and edited the manuscript; Kotov AN collected and analyzed the obtained data and performed statistical analysis; Baranov MV collected and analyzed the obtained data and edited the manuscript.

Compliance with ethical standards: the study was approved by the Ethics Committee of Federal Research Clinical Center of FMBA (Protocol № 1 dated February 7, 2019) and conformed with the principles of biomedical ethics laid out in the Declaration of Helsinki (the 1964 version and subsequent updates); voluntary informed consent was obtained from each study participant.

Received: 2020-10-07 Accepted: 2020-11-23 Published online: 2020-12-14
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  1. Gazenko OG, Grigoriev AI, Egorov AD. Reakcii organizma cheloveka v uslovijah kosmicheskogo poleta. V knige: Gazenko OG, Kasjan II, redaktory. Fiziologicheskie problemy nevesomosti. M., 1990; s. 15–48. Russian.
  2. Charles JB, Bungo MW, Fortner GW. Cardiopulmonary function. In: Nicogossian AE, Huntoon CL, Pool S, editors. Space Physiology and Medicine. 3rd ed. Lea & Febiger. A Waverly Company; 1994. Section III, Chart.14, p. 286–304.
  3. Meck JV, Reyes CJ, Perez SA, Goldberger AL, Ziegler MG. Marked exacerbation of orthostatic intolerance after long- vs. short-duration spaceflight in veteran astronauts. Psychosom Med. 2001; 63: 865–73.
  4. Lee SMC, Feiveson AH, Stein S, Stenger MB, Platts SH. Orthostatic intolerance after ISS and Space Shuttle missions. Aerosp Med Hum Perform. 2015; 86 (12 Suppl.): A54–67.
  5. Kozlovskaya IB, Yarmanova EN, Egorov AD, Stepantsov VI, Fomina EV, Tomilovskaya ES i dr. Razvitie rossijskoj sistemy profilaktiki neblagoprijatnyh vlijanij nevesomosti v dlitel'nyh poletah na MKS. V knige: Grigor'ev A. I., redaktor. Mezhdunarodnaja kosmicheskaja stancija. Rossijskij segment. M.: Uchrezhdenie RAN Gosudarstvennyj nauchnyj centr RF — Institut mediko-biologicheskih problem, 2011; 1: 63–98. Russian.
  6. Kotovskaya AR, Fomina GA. Serdechno-sosudistaya sistema cheloveka. In: Grigoriev AI, Ushakov IB, redaktory. Kosmicheskaja medicina i biologija: sbornik nauchnyh statej. Voronezh: IPC «Nauchnaja kniga», 2013; s. 306–20. Russian.
  7. Baranov VM, Katuntsev VP, Baranov MV, Shpakov AV, Tarasenkov GG. Vyzovy kosmicheskoj medicine pri osvoenii chelovekom Luny: riski, adaptacija, zdorov'e, rabotosposobnost'. Ul'janov. med-biol. zhurnal. 2018; 3: 109–23. Russian.
  8. Kotov AN, Zakharov SYu, Rudenko EA, Baranov VM. Vlijanie mnogosutochnoj antiortostaticheskoj i ortostaticheskoj gipokinezii na ortoustojchivost' cheloveka. Medicina jekstremal'nyh situacij. 2016; 1: 25–9. Russian.
  9. Orlov OI, Koloteva MI, Shipov AA. Issledovaniya na ustanovkakh medlennogo vrashcheniya. In: Grigorev AI, Ushakov IB, redaktory. Kosmicheskaja medicina i biologija: sbornik nauchnyh statej. Voronezh: IPC «Nauchnaja kniga», 2013; s. 562–9. Russian.
  10. Solopov I. N. Podgotovka cheloveka k dlitel'nomu kosmicheskomu poletu v uslovijah modelirovanija jekstremal'nyh situacij. Medicina jekstremal'nyh situacij. 2016; 1: 71–5. Russian.
  11. Meerson F. Z. Obshhij mehanizm adaptacii i profilaktiki. M.: Medicina, 1973; 360 s. Russian.
  12. Ushakov IB, Bukhtiyarov IV, Shishov AA, Olenev NI. Gipobaricheskaja interval'naja gipoksija kak metod dlja povyshenija ustojchivosti k vozdejstviju professional'no vrednyh faktorov. Vestnik Ros. akademii med. nauk. 2010; 12: 3–7. Russian.
  13. Serebrovskaya T, Xi L. Intermittent hypoxic training as non-pharmacological therapy for cardiovascular diseases: Practical analysis on methods and equipment. Exp Biol Med. 2016; 241 (15): 1708–23.
  14. Lesova EM, Filippova EB, Golubev VN, Dergachev VB. Vlijanie interval'nyh gipoksicheskih trenirovok na pokazateli gemodinamiki pri ortostaticheskoj nagruzke. Vestn. Ross. voenn.-med. akad. 2015; 3 (51): 109–13. Russian.
  15. Donina ZhA. Rol' gipoksicheskogo vozdejstvija v snizhenii ortostaticheskih rasstrojstv posle prebyvanija v uslovijah modelirovannoj nevesomosti. Medicina jekstremal'nyh situacij. 2016; 1: 63–70. Russian.
  16. Donina ZhA, Baranova EV, Aleksandrova NP, Katuntcev VP, Baranov VM. Normobaricheskaja periodicheskaja gipoksija povyshaet ortostaticheskuju rezistentnost' krys posle modelirovannoj nevesomosti. Ros. fiziol. zhurn. im. IM. Sechenova. 2018; 104 (11): 1301–12. Russian.
  17. Genin AM, Pestov ID. Mikrogravitacija: mehanizmy i modeli. V knige: Antipov VV, Grigorev AI, Lich Hantun K, redaktory. Chelovek v kosmicheskom polete. M.: Nauka, 1997; s. 460–80. Russian.
  18. Pavy-Le Traon A, Sigaudo D, Vasseur P, Fortrat JO, Güell A, Hughson RL, et al. Orthostatic tests after a 4-day confinement or simulated weightlessness. Clinical Physiology. 1997; 17: 41–55.
  19. Arbeille P, Sigaudo D, Pavy Le Traon A, Herault S, Porcher M, Gharib C. Femoral to cerebral arterial blood flow redistribution and femoral vein distension during orthostatic tests after 4 days in the head-down tilt position or confinement. European Journal of Applied Physiology and Occupational Physiology. 1998; 78: 208–18.
  20. Butler GC, Xing H, Northey DR, Hughson RL. Reduced orthostatic tolerance following 4 h head-down tilt. Eur J Appl Physiol. 1991; 62: 26–30.
  21. Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J et al. Effects of prolonged head-down bed rest on cardiac and vascular baroreceptor modulation and orthostatic tolerance in healthy individuals. Frontiers in Physiology. 2019; 10. Article 1061.
  22. Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J. From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006). Eur Journal of Applied Physiology. 2007; 101: 143–94.
  23. Osadchy LI. Polozhenie tela i reguljacija krovoobrashhenija. L.: Nauka, 1982; 145 c. Russian.
  24. Norsk P, Asmar A, Damgaard M, Christensen NJ. Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight. J Physiol. 2015; 593 (3): 573–84.
  25. Convertino VA, Doerr DF, Eckberg DL, Fritsch JM, Vernikos- Danellis J. Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J Appl Physiol. 1990; 68 (4): 1458–64.
  26. Katkov VE, Chestukhin VV, Nikolaenko EM, Rumyantsev VV, Gvozdev SV. Central'noe krovoobrashhenie zdorovogo cheloveka vo vremja 7-sutochnoj antiortostaticheskoj gipokinezii i dekompressii razlichnyh oblastej tela. Kosmicheskaja biologija i aviakosmicheskaja medicina. 1984; 1: 80–90. Russian.
  27. Maillet A, Pavy-Le Traon A, Allevard AM, Sigaudo D, Hughson RL, Gharib C, et al. Hormone changes induced by 37.5-h head-down tilt (-6). J Appl Physiol. 1994; 68: 497–503.
  28. Lobachik VI, Abrosimov SV, Zhidkov VV, Endeka DK. Hemodynamic effects of microgravity and their groundbased simulations. 8th IAA Man in space symposium. Acta Astronaut. 1991; 23: 35–40.
  29. Johansen LB, Gharib C, Allevard AM, Sigaudo D, Christensen NJ, Drummer C. et al. Haematocrit, plasma volume and noradrenaline in humans during simulated weightlessness for 42 days. Clin Physiol. 1997; 17: 203–10.
  30. Amirova L, Navasiolava N, Rukavishvikov I, Gauquelin-Koch G, Gharib C, Kozlovskaya I, et al. Cardiovascular system under simulated weightlessness: head-down bed rest vs. dry immersion. Frontiers in Physiology. 2020: 11. Article 3952020.
  31. Arbeille P, Fomina G, Roumy J, Alferova I, Tobal N, Herault S. Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short-and long-term headdown tilt and spaceflights. Europ J Appl Physiol. 2001; 86: 157–68.
  32. Kotovskaya AR, Fomina GA, Salnikov VA. Issledovanija sostojanija ven goleni kosmonavtov v povtornyh 6-mesjachnyh kosmicheskih poletah na RS MKS. Aviakosmich. i jekologich. med. 2019; 53 (1): 44–8. Russian.
  33. Taylor CE, Witter T, Sayed K, Hissen SL, Johnson AW, Macefield VG. Relationship between spontaneous sympathetic baroreflex sensitivity and cardiac baroreflex sensitivity in healthy young individuals. Physiol Rep. 2015; 3 (11): 1–10.
  34. Hart EC, Joyner MJ, Wallin BG, Karlsson T, Curry TB, Charkoudian N. Baroreflex control of muscle sympathetic nerve activity: a nonpharmacological measure of baroreflex sensitivity. Am J Physiol Heart Circ Physiol. 2009; 298: H816–22.
  35. Buckey JC, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, et al. Orthostatic intolerance after spaceflight. J Appl Physiol. 1996; 81 (1): 7–18.
  36. Platts SH, Ziegler MG, Waters WW, Meck JV. Hemodynamic effects of midodrine after space flight in astronauts without orthostatic hypotension. Aviat Space Environ Med. 2006; 77: 429–33.
  37. Lukyanova LD. Signal'nye mehanizmy gipoksii. M.: RAN, 2019; 215 c. Russian.
  38. Bobyleva OV, Glazachev OS. Dinamika pokazatelej vegetativnoj reaktivnosti i ustojchivosti k ostroj dozirovannoj gipoksii v kurse interval'noj gipoksicheskoj trenirovki. Fiziologija cheloveka. 2007; 33 (2): 81–9. Russian.
  39. Balykin MV, Sagidova SA, Zhirkov AS, Ayzyatulova ED, Pavlov DA, Antipov IV. Vlijanie preryvisnoj gipobaricheskoj gipoksii na jekspressiju HIF-1α i morfofunkcional'nye izmenenija v miokarde. Ul'janov. med-biol. zhurnal. 2017; (2): 125–34. Russian.