2021 / 01

DOI: 10.47183/mes.2021.009

ORIGINAL RESEARCH

Еvaluation of antitumor activity of some 4-aminopiperidine derivatives — low molecular weight Hsp70 inhibitors — on transplantable mouse tumors

Aldobaev VN1, Mikhina LV1, Present MA2
About authors

1 Research Centre for Toxicology and Hygienic Regulation of Biopreparations of FMBA, Serpukhov, Russia

2 Zelinsky Institute of Organic Chemistry, Moscow, Russia

Correspondence should be addressed: Vladimir N. Aldobaev
Lenina, 102A, pos. Bolshevik, Moscow oblast,142283; ur.oibcixot@veabodla

About paper

Funding: the study was carried out under the State Assignment for FMBA № 22.001.18.800.

Author contribution: Aldobaev VN planned the experiment, summarized its results and wrote this manuscript; Mikhina LV carried out the experiment in animal models; Present MA synthesized the tested compounds.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Centre for Toxicology and Hygienic Regulation of Biopreparations (Protocol № 695 dated November 12, 2019). Housing conditions met the requirements of Sanitary Regulations 2.2.1.3218-14 (Sanitary and Epidemiological Requirements for Design, Equipment and Maintenance of Vivarium Facilities) and the guidelines provided in the Guide for Care and Use of Laboratory Animals (ILAR publication, 1996, National Academy Press, USA).

Received: 2021-02-13 Accepted: 2021-03-12 Published online: 2021-03-21
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