2021 / 02

DOI: 10.47183/mes.2021.019

METHOD

Method for quantitative assessment of protective immunity against SARS-CoV-2, its duration and antibody dynamics

Karmishin AM1, Nosov NYu1, Postupailo VB1, Zhigarlovskiy BA1, Kruglov AA1, Petukhov AN2
About authors

1 Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, Moscow, Russia

2 Military Academy of Radiation, Chemical and Biological Defense, Kostroma, Russa

Correspondence should be addressed: Alexandr M. Karmishin
Shchukinskaya, 5/6, Moscow, 123182; ur.zmpsc@nihsimraka

About paper

Author contribution: All authors equally contributed to the methodology of the study, data acquisition, analysis and interpretation. All author participated in drafting the manuscript and editing its final version.

Received: 2021-05-25 Accepted: 2021-06-07 Published online: 2021-06-28
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Fig. 1. The dependence of the hazard factor law on IgG antibody titers
Fig. 2. The linear representation of the distribution law for random IgM and IgG titers
Fig. 3. The dynamics of median IgM (А) and IgG (B) titers over time
Fig. 4. The graphic representation of the solution to the problem of protective immunity duration
Table 1. Grouped data on IgM (n = 11) and IgG (n = 38) titers
Note: AU — arbitrary unit: the diagnostic system employed for quantitative analysis returned the results in its own units of measurement different from the international units of measurement.
Table 2. Estimates of equation (7) parameters
Table 3. Distribution parameters for a random antibody titer at a given point in time after exposure and statistical estimates