REVIEW

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection

Lobzin YuV1,2,4, Uskov AN1, Skripchenko NV1,3, Vilnits AA1,3, Bekhtereva MK1,3, Babachenko IV1,3
About authors

1 Pediatric Research and Clinical Center for Infectious Diseases of FMBA, Saint Petersburg, Russia

2 Mechnikov North-West State Medical University, Saint Petersburg, Russia

3 Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia

4 Kirov Military Medical Academy, Saint Petersburg, Russia

Correspondence should be addressed: Alla A. Vilnits
Professora Popova, 9, Saint Petersburg, 197022; ur.liam@ztinliv

About paper

Author contribution: Lobzin YuV, Uskov AN, Skripchenko NV — study concept and design; Vilnits AA, Bekhtereva MK, Babachenko IV — data acquisition and processing, statistical analysis, manuscript preparation; Skripchenko NV — editing.

Received: 2021-06-07 Accepted: 2021-06-21 Published online: 2021-06-26
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Despite the low incidence, low mortality and relatively mild symptoms of COVID-19 in children, there has been a rise in pediatric patients who develop a condition resembling Kawasaki disease after COVID-19 or contact with individuals infected with SARS-CoV-2. This condition is known as the pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS).  This review introduces the reader to the hypotheses of PIMS-TS pathogenesis, provides information about its diagnosis and treatment, presents clinical and laboratory data and describes treatments strategies used in children and adolescents hospitalized to the intensive care unit of the Pediatric Research and Clinical Center for Infectious Diseases. Besides, the review outlines the main diagnostic and prognostic challenges of PIMS-TS.

Keywords: children, COVID-19, SARS-CoV-2, coronavirus infection, SARS-COV-2, multisystem inflammatory syndrome

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