2021 / 02

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DOI: 10.47183/mes.2021.017

REVIEW

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection

Lobzin YuV1,2,4, Uskov AN1, Skripchenko NV1,3, Vilnits AA1,3, Bekhtereva MK1,3, Babachenko IV1,3
About authors

1 Pediatric Research and Clinical Center for Infectious Diseases of FMBA, Saint Petersburg, Russia

2 Mechnikov North-Western State Medical University, Saint Petersburg, Russia

3 Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia

4 Kirov Military Medical Academy, Saint Petersburg, Russia

Correspondence should be addressed: Alla A. Vilnits
Professora Popova, 9, Saint Petersburg, 197022; ur.liam@ztinliv

About paper

Author contribution: Lobzin YuV, Uskov AN, Skripchenko NV — study concept and design; Vilnits AA, Bekhtereva MK, Babachenko IV — data acquisition and processing, statistical analysis, manuscript preparation; Skripchenko NV — editing.

Received: 2021-06-07 Accepted: 2021-06-21 Published online: 2021-06-26
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  1. WHO Coronavirus (COVID-19) Dashboard. 2021 Apr (cited 2021 Apr 07). Available from: https://covid19.who.int/ .
  2. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 2020; 109: 1088–95. PMID: 32202343 DOI: 10.1111/apa.15270.
  3. Ding Y, Yan H, Guo W. Clinical Characteristics of Children with COVID-19: A Meta-Analysis. Front Pediatr 2020; 8: 431. PMID: 32719759 DOI: 10.3389/fped.2020.00431.
  4. Guo CX, He L, Yin JY, Meng XG, Tan W, Yang GP, et al. Epidemiological and clinical features of pediatric COVID-19. BMC Med 2020; 18: 250. PMID: 32762696 DOI:10.1186/s12916-02001719-2.
  5. Uskov AN, Lobzin JuV, Rychkova SV, Babachenko IV, Fedorov VV, Uluhanova LU i dr. Techenie novoj koronavirusnoj infekcii u detej: nekotorye aspekty monitoringa zabolevaemosti i analiza letal'nosti. Zhurnal infektologii. 2020; 12 (3): 12–20. DOI: 10.22625/20726732-2020-12-3-12-20. Russian.
  6. Leidman E, Duca LM, Omura JD, Proia K, Stephens JW, SauberSchatz EK. COVID-19 Trends Among Persons Aged 0—24 Years — United States, March 1-December 12, 2020. MMWR Morb Mortal Wkly Rep. 2021; 70 (3): 88–94. DOI: 10.15585/mmwr. mm7003e1. PMID: 33476314; PMCID: PMC7821770.
  7. Jones VG, Mills M, Suarez D, Hogan CA, Yeh D, Segal JB, et al. COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hosp Pediatr. 2020; 10 (6): 537–40. DOI: 10.1542/ hpeds.2020-0123. Epub 2020 Apr 7. PMID: 32265235.
  8. Davies P, Evans C, Kanthimathinathan HK, Lillie J, Brierley J, Waters G, et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health. 2020; 4 (9): 669–77. DOI: 10.1016/S2352-4642(20)30215-7. PMID: 32653054; PMCID: PMC7347350.
  9. Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020; 395 (10239): 1771–8. DOI: 10.1016/S01406736(20)31103-X. PMID: 32410760; PMCID: PMC7220177.
  10. Rowley AH. Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children. Nat Rev Immunol. 2020; 20 (8): 453–4. DOI: 10.1038/s41577-020-0367-5. PMID: 32546853; PMCID: PMC7296515.
  11. Evans C, Davies P. SARS-CoV-2 paediatric inflammatory syndrome. Paediatr Child Health (Oxford). 2021; 31 (3): 110–5. DOI: 10.1016/j.paed.2020.12.003. PMID: 33391390; PMCID: PMC7762804.
  12. Dolhnikoff M, Ferreira Ferranti J, de Almeida Monteiro RA, DuarteNeto AN, Soares Gomes-Gouvêa M, Viu Degaspare N, et al. SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome. Lancet Child Adolesc Health. 2020; 4 (10): 790–4. DOI: 10.1016/S2352-4642(20)30257-1. PMID: 32828177; PMCID: PMC7440866.
  13. Bregel LV, Kostik MM, Fell LZ, Efremova OS, Soboleva MK, Krupskaja TS i dr. Bolezn' Kavasaki i mul'tisistemnyj vospalitel'nyj sindrom pri infekcii COVID-19 u detej. Pediatrija im. G. N. Speranskogo. 2020; 99 (6): 209–19. DOI: 10.24110/0031-403X2020-99-6-209-219. Russian.
  14. Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, et al. 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Ann Rheum Dis. 2016;75(3):481–9. DOI: 10.1136/annrheumdis-2015-208982. PMID: 26865703.
  15. Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020; 369: m2094. DOI: 10.1136/bmj.m2094. PMID: 32493739; PMCID: PMC7500538.
  16. Consiglio C, Cotugno N, Sardh F, et al. The immunology of multisystem inflammatory syndrome in children with COVID-19. 2020; 12; 183 (4): 968–81.e7. DOI: 10.1016/j.cell.2020.09.016. PMID: 32966765; PMCID: PMC7474869.
  17. Gruber CN, Patel RS, Trachtman R, Lepow L, Amanat F, Krammer F, et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Cell. 2020; 183 (4): 982–95.e14. DOI: 10.1016/j.cell.2020.09.034. PMID: 32991843; PMCID: PMC7489877.
  18. Hoste L, Van Paemel R, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021; 18: 1–16. DOI: 10.1007/s00431-021-039935. PMID: 33599835; PMCID: PMC7890544.
  19. Yasuhara J, Watanabe K, Takagi H, Sumitomo N, Kuno T. COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis. Pediatr Pulmonol. 2021; 11: 10.1002/ppul.25245. DOI: 10.1002/ppul.25245. PMID: 33428826; PMCID: PMC801339.
  20. Tang Y, Li W, Baskota M, Zhou Q, Fu Z, Luo Z, et al. Multisystem inflammatory syndrome in children during the coronavirus disease 2019 (COVID-19) pandemic: a systematic review of published case studies. Transl Pediatr. 2021; 10 (1): 121–35. DOI: 10.21037/ tp-20-188. PMID: 33633944; PMCID: PMC7882293.
  21. Daskalakis D. Health Alert# 13: pediatric multi-system inflammatory syndrome potentially associated with COVID-19 // NYC Health [Internet]. 2020 May [cited 2021 Apr 07]. Available from: https://www1.nyc.gov/assets/doh/downloads/pdf/han/ alert/2020/covid-19-pediatric-multi-system-inflammatorysyndrome.pdf.
  22. Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K, et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine. 2020; 26: 100527. DOI: 10.1016/j.eclinm.2020.100527. PMID: 32923992; PMCID: PMC7473262.
  23. Jindal AK, Pilania RK, Prithvi A, Guleria S, Singh S. Kawasaki disease: characteristics, diagnosis, and unusual presentations. Expert Rev Clin Immunol. 2019; 15 (10): 1089–104. DOI: 10.1080/1744666X.2019.1659726. PMID: 31456443.
  24. Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. PIMS-TS Study Group and EUCLIDS and PERFORM Consortia. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020; 324 (3): 259–69. DOI: 10.1001/ jama.2020.10369. PMID: 32511692; PMCID: PMC7281356.
  25. Wu L, O'Kane AM, Peng H, Bi Y, Motriuk-Smith D, Ren J. SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management. Biochem Pharmacol. 2020; 178: 114114. DOI: 10.1016/j.bcp.2020.114114. PMID: 32579957; PMCID: PMC7306106.
  26. Royal College of Paediatric and Child Health. Guidance: paediatric multisystem inflammatory syndrome temporally associated with COVID-19. 2020 May 01 (cited 2021 Apr 07). Available from: https://www.rcpch.ac.uk/resources/guidance-paediatricmultisystem-inflammatory-syndrome-temporally-associatedcovid-19.
  27. Cuomo AM, Zucker HA, Dreslin S. Health advisory: pediatric multi-system inflammatory syndrome potentially associated with сoronavirus disease (COVID-19) children //New York State of Opportunity. Department of Health. 2020 May 06 (cited 2021 Jan 24). Available from: https://www.health.ny.gov/ press/releases/2020/docs/2020-05- 06_covid19_pediatric_ inflammatory_syndrome.pdf.
  28. Lobzin JuV, Vilnic AA, Kostik MM i dr. Pediatricheskij mul'tisistemnyj vospalitel'nyj sindrom, associirovannyj s novoj koronavirusnoj infekciej: nereshennye problemy. Zhurnal infektologii. 2021; 13 (1): 13–20. https://doi.org/10.22625/2072-6732-2021-13-1-13-20. Russian.
  29. Kawasaki T. Kawasaki disease. Proc Jpn Acad Ser B Phys Biol Sci. 2006; 82 (2): 59–71. DOI: 10.2183/pjab.82.59. PMID: 25792773; PMCID: PMC4323050.
  30. Kawasaki T. Kawasaki disease. Int J Rheum Dis. 2014; 17 (5): 597–600. DOI: 10.1111/1756-185X.12408.
  31. Aleksandrovich JuS, Alekseeva EI, Bakradze MD i dr. Osobennosti klinicheskih projavlenij i lechenija zabolevanija, vyzvannogo novoj koronavirusnoj infekciej (COVID-19), u detej. Metodicheskie rekomendacii. Versija 2. Pediatricheskaja farmakologija. 2020; 17 (3): 187–212. DOI: 10.15690/pf.v17i3.2123. Russian.