ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
Copyright: © 2022 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Antimicrobial and antiviral activity of three-component complex of chlorhexidine-edta-zinc
About authors
1 OOO ”ROSBIO”, St. Petersburg, Russia
2 Federal State-Financed Institution Golikov Research Clinical Center of Toxicology under the Federal Medical Biological Agency, St. Petersburg, Russia
3 Institute of Analytical Instrumentation, St. Petersburg, Russia
4 Saint Petersburg State University, St Petersburg, Russia
5 Saint-Petersburg State Research Institute of Phtisiopulmonology, St. Petersburg, Russia
Correspondence should be addressed: Konstantin A. Krasnov
Bekhtereva, 1/2, k. 54, St. Petersburg, 199106, Russia; ur.liam@xot_vonsark
About paper
Funding: ООО "ROSBIO"
Author contribution: Galinkin VA — organization of microbiological and virological research; Enikeev AKh — general management; Podolskaya EP — mass spectrometric analysis, Gladchuk AS — chemical-analytical studies; Vinogradova TI — management of studies of anti-tuberculosis activity; Zabolotnykh NV — study of antitubercular activity in vitro; Dogonadze MZ — study of antitubercular activity in animals; Krasnov KA — data processing and interpretation, preparation of the materials for publication.
Compliance with ethical standards: all procedures with animal models were carried out in accordance with the Directive 2010/63/EU of the European Parliament and of the Council of the European Union (2010) on protection of animals used for scientific purposes.
Received: 2021-12-27
Accepted: 2022-01-24
Published online: 2022-02-07
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Fig. 1. Changes in the intensity of growth of the M. tuberculosis H37Rv test strain under the influence of the CHX-EDTA-Zn complex. The abscissa shows the drug concentration, the ordinate shows the average fluorescence intensity in conventional units, M is the mean value, (M-I) and (M+I) are the lower and upper limits of the confidence interval (at α = 0.05)
Fig. 2. Structural formula of the chlorhexidine-EDTA-zinc complex
Table 1. Antimicrobial activity of the CHX-EDTA-Zn complex in comparison with chlorhexidine bigluconate (CHX)
Table 2. CHX-EDTA-Zn complex activity against avian pathogens
Note: «–» — complete absence of growth; "+" — growth of single colonies; "+" — normal growth.
Table 3. CHX-EDTA-Zn complex efficacy indicators in treatment of dermatitis in animals
Table 4. Tuberculosis infection severity in mice infected with M. tuberculosis H37Rv and infected with drug-resistant strain 5582 (after 5 weeks from the start of the treatment)
Table 5. Inoculation of MBT from the lungs of mice infected with M. tuberculosis H37R and strain 5582 after 5 weeks of treatment with the CHX-EDTA-Zn complex
Table 6. Virucidal activity of the CHX-EDTA-Zn complex
