ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
Copyright: © 2022 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Status of factors of innate immunity in exposed people who subsequently developed cancer
About authors
1 Urals Research Center for Radiation Medicine of the Federal Medical Biological Agency, Chelyabinsk, Russia
2 Chelyabinsk State University, Chelyabinsk, Russia
3 South Ural State Medical University, Chelyabinsk, Russia
Correspondence should be addressed: Eugenia A. Blinova
Vorovsky, 68-А, Chelyabinsk, 454141, Russia; ur.mrcru@avonilb
About paper
Funding: the study was carried out with financial support from the Federal Medical Biological Agency of Russia within the framework of the Federal Target Program “Nuclear and Radiation Safety in 2016-2020 and until 2030” (State Contract № 11.313.21.2 of 15 June 2021).
Author contribution: Blinova EA — synthesis of primary data, analysis and discussion of the results, manuscript writing; Kotikova AI — statistical processing of primary data; Akleyev AA, Akleyev AV — study planning, manuscript editing, preparation of the final version of the article.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Urals Research Center for Radiation Medicine (protocol № 4 of 23 August 2022). All patients submitted the informed consent to study participation.
Received: 2022-08-26
Accepted: 2022-09-14
Published online: 2022-09-29
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Fig. 1. Linear regression analysis of the dose–response relationships in the group of exposed people who subsequently developed cancer for the following indicators: А — relative eosinophil counts, B — phagocytosis rate of monocytes, C — phagocytic activity of neutrophils
Fig. 2. Linear regression analysis of the dose-dependent decrease in basophil counts for: А — accumulated dose to RBM, B — accumulated dose to thymus and peripheral lymphoid organs
Fig. 3. Linear regression analysis of the dose-dependent increase in the monocyte phagocytic index, comparison group
Table 1. Characteristics of studied groups
Note: n — number of surveyed people; M ± SE — mean ± standard error of the mean; p — significance levels for intergroup differences.
Table 2. Quantity of innate immune cells in blood of examined individuals
Note: Mе (Q1 – Q2 ) — median (25th–75th percentile range).
Table 3. Functional characteristics of innate immune cells in the examined individuals
Note: Mе (Q1 – Q2 ) — median (25th–75th percentile range); ** — significant differences between the studied groups.
