2022 / 03

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DOI: 10.47183/mes.2022.034

ORIGINAL RESEARCH

Status of factors of innate immunity in exposed people who subsequently developed cancer

Blinova EA1,2, Kotikova AI1,2, Akleyev AA3, Akleyev AV1,2
About authors

1 Urals Research Center for Radiation Medicine of the Federal Medical Biological Agency, Chelyabinsk, Russia

2 Chelyabinsk State University, Chelyabinsk, Russia

3 South Ural State Medical University, Chelyabinsk, Russia

Correspondence should be addressed: Evgenia A. Blinova
Vorovsky, 68-А, Chelyabinsk, 454141, Russia; ur.mrcru@avonilb

About paper

Funding: the study was carried out with financial support from the Federal Medical Biological Agency of Russia within the framework of the Federal Target Program “Nuclear and Radiation Safety in 2016-2020 and until 2030” (State Contract № 11.313.21.2 of 15 June 2021).

Author contribution: Blinova EA — synthesis of primary data, analysis and discussion of the results, manuscript writing; Kotikova AI — statistical processing of primary data; Akleyev AA, Akleyev AV — study planning, manuscript editing, preparation of the final version of the article.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Urals Research Center for Radiation Medicine (protocol № 4 of 23 August 2022). All patients submitted the informed consent to study participation.

Received: 2022-08-26 Accepted: 2022-09-14 Published online: 2022-09-29
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  1. Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nature Immunology. 2013; 14 (10): 1014–22. DOI: 10.1038/ni.2703.
  2. Dolgushin II, Andreeva YuS, Savochkina AYu. Neutrophil traps and methods for assessing the functional status of neutrophils. M.: Izdatelstvo RAMN, 2009; 207 p. Russian.
  3. Petrov RV, Khaitov RM. Immunogens and vaccines of a new generation. M.: GEOTAR-Media, 2011; 608 p. Russian.
  4. Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Current Opinion in Immunology. 2010; 22 (2): 231–37. DOI: 10.1016/j.coi.2010.01.009.
  5. Akleyev АА. Immune status of a man long after chronic radiation exposure. Medical Radiology and Radiation Safety. 2020; 65 (4): 29–35. DOI: 10.12737/1024-6177-2020-65-4-29-35. Russian.
  6. Kodintseva EA, Akleyev АА, Blinova ЕА. The cytokine profile of chronically irradiated people in long terms after the beginning of irradiation. Radiation biology Radioecology. 2021; 61 (5): 495–503. DOI: 10.31857/S0869803121050076. Russian.
  7. Blinova ЕА, Akleyev АА, Kodintseva EA, Akleyev AV. The study of the functional status of the system of neutrophilic granulocytes, monocytes and natural killers in chronically exposed individuals with obligate forms of pre-malignant conditions. South Ural Medical Journal. 2021; 2: 5–17. Russian.
  8. Schonfeld S, Krestinina LY, Epifanova S, et al. Solid cancer mortality in the Techa River Cohort (1950–2007). Radiation Research. 2013; 179: 183–9.
  9. Krestinina LYu, Silkin SS, Degteva MO, Akleyev AV. Risk analysis of the mortality from the diseases of the circulatory system in the Ural cohort of emergency-irradiated population for the years 1950–2015. Radiation Hygiene. 2019; 12 (1): 52–61. DOI: 10.21514/1998-426X-2019-12-1-52-61. Russian.
  10. Akleyev AV, editor. Consequences of radioactive contamination of the river Techa. Chelyabinsk: Book, 2016; 400 p. Russian.
  11. Degteva MO, Napier BA, Tolstykh EI. Individual dose distribution in cohort of people exposed as a result of radioactive contamination of the Techa river. Medical radiology and radiation safety. 2019; 64 (3): 46–53. DOI: 10.12737/article_5cf2364cb49523.98590475. Russian.
  12. Mayanskii AN, Viksman MK. A method for assessing the functional activity of human neutrophils by the reduction reaction of nitroblue tetrazolium: guidelines. Kazan, 1979; 11 p. Russian.
  13. Freidlin IS. Methods for studying phagocytic cells in assessing the immune status of a person: a textbook. Leningrad, 1986; 37 p. Russian.
  14. Koch J, Hau J, Pravsgaard CJ, et al. Immune cells from SR/ CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice. PLoS One. 2013; 8 (5). Available from: https://journals.plos.org/plosone/article?id=10.1371/journal. pone.0059995.
  15. Nesterova IV, Kovaleva SV, Chudilova GA, et al. The dual role of neutrophils in the antitumor protection. Immunology. 2012; 33 (5): 281–7. Russian.
  16. Queen MM, Ryan RE, Holser RG, et al. Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression. Cancer Research. 2005; 65: 8896–904. DOI: 10.1158/0008-5472.CAN-05-1734.
  17. Thomas SN, Zhu F, Schnaar RL, et al. Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. Journal of Biological Chemistry. 2008; 283 (23): 15647–55. DOI: 10.1074/ jbc.M800543200.
  18. De Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nature Reviews Cancer. 2006; 6 (1): 24–37. DOI: 10.1038/nrc1782.
  19. Akleyev АА, Dolgushin II, Blinova ЕА. Study of neutrophil count dynamics in exposed persons during the period prior to acute leukemias development. Russian journal of immunology. 2019; 13 (4, 22): 1423–5.