ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
Copyright: © 2023 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Assessment of the effect of chronic exposure on premature aging of human T-lymphocytes based on unstable chromosome aberrations
About authors
Ural Research Center for Radiation Medicine, Chelyabinsk, Russia
Correspondence should be addressed: Alexandra V. Vozilova
Vorovsky, 68 A, Chelyabinsk, 454141, Russia; ur.mrcru@avolizov
About paper
Funding: the work supported financially by the Federal Medical Biological Agency of Russia as part of the research effort under the State Assignment.
Acknowledgements: the author thanks YaV Krivoshchapova, junior researcher, NF Savkova, senior laboratory assistant, for technical and laboratory support.
Compliance with ethical standards: the study was approved by the ethics committee of the Urals Research Center for Radiation Medicine (Minutes № 5 of December 20, 2022); all the cytogenetic study participants signed a voluntary informed consent for blood sampling and further analysis.
Received: 2023-01-13
Accepted: 2023-05-15
Published online: 2023-06-10
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Table 1. Frequency (%) of unstable chromosomal aberrations in the examined groups (median, 25 and 75%)
Note: р — statistical differences in indicators between similar age subgroups of the exposed and control groups; р1 — statistical differences in indicators between age subgroups "40–59 years old" and "60–69 years old"; р2 — statistical differences in indicators between age subgroups "40–59 years old" and "70–79 years old"; M — male; F — female.
Table 2. Dynamics of frequency (%) of unstable exchange-type chromosome aberrations in the same exposed individuals examined in different age subgroups
Note: р — statistical differences in the final indicators as registered between subgroups.
