ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Assessment of the effect of chronic exposure on premature aging of human T-lymphocytes based on unstable chromosome aberrations
About authors
Ural Research Center for Radiation Medicine, Chelyabinsk, Russia
Correspondence should be addressed: Alexandra V. Vozilova
Vorovsky, 68 A, Chelyabinsk, 454141, Russia; ur.mrcru@avolizov
About paper
Funding: the work supported financially by the Federal Medical Biological Agency of Russia as part of the research effort under the State Assignment.
Acknowledgements: the author thanks YaV Krivoshchapova, junior researcher, NF Savkova, senior laboratory assistant, for technical and laboratory support.
Compliance with ethical standards: the study was approved by the ethics committee of the Urals Research Center for Radiation Medicine (Minutes № 5 of December 20, 2022); all the cytogenetic study participants signed a voluntary informed consent for blood sampling and further analysis.
Received: 2023-01-13
Accepted: 2023-05-15
Published online: 2023-06-10
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Table 1. Frequency (%) of unstable chromosomal aberrations in the examined groups (median, 25 and 75%)
Note: р — statistical differences in indicators between similar age subgroups of the exposed and control groups; р1 — statistical differences in indicators between age subgroups "40–59 years old" and "60–69 years old"; р2 — statistical differences in indicators between age subgroups "40–59 years old" and "70–79 years old"; M — male; F — female.
Table 2. Dynamics of frequency (%) of unstable exchange-type chromosome aberrations in the same exposed individuals examined in different age subgroups
Note: р — statistical differences in the final indicators as registered between subgroups.
