ORIGINAL RESEARCH

Assessment of the effect of chronic exposure on premature aging of human T-lymphocytes based on unstable chromosome aberrations

About authors

Ural Research Center for Radiation Medicine, Chelyabinsk, Russia

Correspondence should be addressed: Alexandra V. Vozilova
Vorovsky, 68 A, Chelyabinsk, 454141, Russia; ur.mrcru@avolizov

About paper

Funding: the work supported financially by the Federal Medical Biological Agency of Russia as part of the research effort under the State Assignment.

Acknowledgements: the author thanks YaV Krivoshchapova, junior researcher, NF Savkova, senior laboratory assistant, for technical and laboratory support.

Compliance with ethical standards: the study was approved by the ethics committee of the Urals Research Center for Radiation Medicine (Minutes № 5 of December 20, 2022); all the cytogenetic study participants signed a voluntary informed consent for blood sampling and further analysis.

Received: 2023-01-13 Accepted: 2023-05-15 Published online: 2023-06-10
|
  1. Akleev AV, redaktor. Posledstviya radioaktivnogo zagryazneniya reki Techa. Chelyabinsk, 2016; 400 s. Russian.
  2. Anisimov VN. Molekulyarnye i fiziologicheskie mexanizmy stareniya. Sankt-Peterburg: Nauka, 2008; 481 s. Russian.
  3. Pristrom MS, Pristrom SL, Semenenkov II. Starenie fiziologicheskoe i prezhdevremennoe. Sovremennyj vzglyad na problemu. Mezhdunarodnye obzory: klinicheskaya praktika i zdorov'e. 2017; 5–6. Russian.
  4. Aunan JR, Watson MM, Hagland HR, et al. Molecular and biological hallmarks of ageing. British Journal of Surgery. 2016; 103 (2): 29–46.
  5. López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell. 2013; 153 (6): 1194–217.
  6. Cytogenetic analysis for radiation dose assessment: a manual. International Atomic Energy Agency Technical Reports Series. 2011; 405.
  7. Vozilova AV. Otdalennye citogeneticheskie ehffekty xronicheskogo oblucheniya naseleniya Yuzhnogo Urala [dissertaciya]. M., 1997. Russian.
  8. Vozilova AV, Shagina NB, Degteva MO, et al. Chronic radioisotope effects on residents of the Techa river (Russia) region: cytogenetic analysis more than 50 years after onset of exposure. Mutation Research. 2013; 756 (1–2): 115–8.
  9. Vozilova AV, Akleev AV. The dynamics of unstable chromosome aberrations frequency among people exposed on the Techa river. International Conference "Genetic Consequences of Emergency Radiation Situations" Proceedings of the International conference "Genetic consequences of emergency radiation situations"; 2002 Jun 10–13. M.: Izdatel'stvo Rossijskogo universiteta druzhby narodov, 2002; p. 230–1. Russian.
  10. Kaddour A, Colicchio B, Buron D, et al. Transmission of induced chromosomal aberrations through successive mitotic divisions in human lymphocytes after in vitro and in vivo radiation. Scientific Reports. 2017; 7 (1): 3291.
  11. Bauchinger M. Quantification of low-level radiation exposure by conventional chromosome aberration analysis. Mutation Research. 1995; 339: 177–89.
  12. Lyubimova N, Vorobcova I. Vliyanie vozrasta i nizkodozovogo oblucheniya na chastotu xromosomnyx aberracij v limfocitax cheloveka. Radiacionnaya biologiya. Radioehkologiya. 2007; 47 (1): 80–5. Russian.
  13. Richardson R. Ionizing radiation and aging: rejuvenating an old idea. Aging. 2009; 1 (11): 887–902.
  14. Degteva M, Napier B, Tolstykh E, et al. Enhancements in the Techa River Dosimetry System: TRDS-2016 D code for reconstruction of deterministic estimates of dose from environmental exposures. Health Physics. 2019; 117 (4): 378–87.
  15. Organizaciya Ob"edinennyx Nacij. Komissiya po narodonaseleniyu i razvitiyu. Pyatidesyataya sessiya: 3–7 aprelya 2017 g. Doklad General'nogo sekretarya. Izmenenie vozrastnoj struktury naseleniya i ustojchivoe razvitie. 2017; 29 c. Dostupno po ssylke: https://www.un.org/en/development/desa/population/pdf/commission/2017/documents/ECN920172/ru.pdf. Russian.
  16. Pristrom MS, Sushinskij VEh, Semenenkov II, Artyushhik VV. Xarakteristika fenomena dolgoletiya. Vzglyad na problemu. Mezhdunarodnye obzory: klinicheskaya praktika i zdorov'e. 2017; 5–6. Russian.
  17. Tolstyx EI, Vozilova AV, Degteva MO, Akleev AV. Koncepciya T-kletochnogo roda kak osnova dlya analiza rezul'tatov citogeneticheskix issledovanij pri lokal'nom obluchenii kostnogo mozga. Radiacionnaya biologiya. Radioehkologiya. 2020; 60 (1): 12–25. Russian.
  18. Bonassi1 S, Norppa H, Ceppi1 M, et al. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries. Carcinogenesis. 29 (6): 1178–83.