2023 / 03

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DOI: 10.47183/mes.2023.036

ORIGINAL RESEARCH

Developing and evaluating the effectiveness of wound-healing compounds based on cationic peptides and fullerene

Galkina AA1, Bolyakina DK1, Shatilova AV1, Shatilov AA1, Babikhina MO1, Golomidova AK2, Andreev SM1, Shershakova NN1, Khaitov MR1,3
About authors

1 National Research Center — Institute of Immunology of the Federal Medical Biological Agency, Moscow, Russia

2 Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Moscow, Russia

3 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Anastasiia А. Galkina
Kashirskoe sh., 24, Moscow, 115522, Russia; moc.liamg@aniklag.a.aisatsana

About paper

Funding: the study was conducted as part of the State Assignment of FMBA “Fullerene-21” (code 612.017.1:616.9).

Author contribution: Galkina AA — setting up methodology, laboratory tests, manuscript writing; Bolyakina DK — laboratory tests; Shatilova AV, Shatilov AA, Babikhina MO — laboratory tests; Golomidova AK — setting up methodology; Shershakova NN — setting up methodology, study concept, manuscript writing, research supervision; Andreev SM — setting up methodology, study concept, research supervision; Khaitov MR — study concept, research supervision.

Compliance with ethical standards: the study was approved by the Bioethics Commission of the Institute of Immunology of FMBA of Russia (order № 102 of November 2015) and conducted in accordance with the Directive 2010/63/EU for animal experiments and the Regulations Regarding Research Involving Laboratory Animals in the National Research Center — Institute of Immunology of FMBA of Russia.

Received: 2023-07-28 Accepted: 2023-09-05 Published online: 2023-09-29
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Fig. 1. Bacterial growth intensity under exposure to the AB-1 peptide
Fig. 2. Bacterial growth intensity under exposure to the AB-3 peptide
Fig. 3. Bacterial growth intensity under exposure to the AB-4 peptide
Fig. 4. Bacterial growth intensity under exposure to the ST-10 peptide
Table. List of cationic peptides showing antibacterial activity against E. сoli Dh5α