Frequency of inversions in the T-lymphocyte chromosomes of exposed residents of the Southern Urals

Krivoshchapova YaV, Vozilova AV
About authors

Urals Research Center for Radiation Medicine of the Federal Medical Biological Agency, Chelyabinsk, Russia

Correspondence should be addressed: Yana V. Krivoshchapova
Vorovsky, 68А, Chelyabinsk, 454141, Russia; ur.liam@oh_anay

About paper

Funding: the study was supported in part by the Russian Foundation for Basic Research (RFBR) grant together with the Government of the Chelyabinsk Region (Contract № 20-44-740007\20 of 28.01.2021), as well as by the Federal Target Program of FMBA of Russia “Modernization of Hightech Methods Aimed at Identifying Medical Consequences of Radiation Exposure in Personnel of the Mayak PA and the Population of the Ural Region” (code “Medical Consequences-21”).

Acknowledgments: the authors would like to express their gratitude to Savkova N.F., senior laboratory assistant, for technical and laboratory support.

Author contribution: Vozilova AV — study concept, research priority setting, literature review, manuscript writing; Krivoshchapova YaV — developing criteria for analysis, staining and slide assessment, statistics, manuscript writing.

Compliance with the ethical standards: the study was approved by the Ethics Committee of the Urals Research Center for Radiation Medicine (protocol No. 7 dated 20 October 2023); individuals, who were through cytogenetic testing, submitted the informed consent to blood sampling and further assessment.

Received: 2023-08-08 Accepted: 2023-10-15 Published online: 2023-11-21
Fig. 1. Potential mechanism underlying the emergence of inversion involving the chromosome telomeric region
Fig. 2. Inversion types: chromosomal (А) and chromatid (B) (telomeric region is highlighted in gray)
Fig. 3. Graph of inversion frequency versus age
Fig. 4. Inversion frequency versus absorbed doses in the examined individuals
Table 1. Characteristics of studied groups
Table 2. Frequency of inversions (M ± SD) (median, 25 and 75%) involving telomeric regions in T cells of exposed residents of the Southern Urals (per 100 cells)
Table 3. Inversion frequency versus sex (M ± SD) per 100 cells