2023 / 04

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DOI: 10.47183/mes.2023.050

ORIGINAL RESEARCH

Effect of cystamine on gastric propulsive function and gas exchange in the rat model of radiation-induced myeloablation

Vakunenkova OA1, Ivnitsky JuJu1, Danilova OA2, Schäfer TV2, Rejniuk VL1
About authors

1 Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency, Saint-Petersburg, Russia

2 State Scientific Research Test Institute of the Military Medicine of Defense Ministry of the Russian Federation, Saint-Petersburg, Russia

Correspondence should be addressed: Timur V. Schäfer
Lesoparkovaya, 4, Saint-Petersburg, 195043, Russia; ur.xednay@refahcs

About paper

Author contribution: Vakunenkova OA — experimental procedure; Ivnitsky JuJu — rationale, developing the experimental model, data interpretation and discussion; Danilova OA — tissue biochemistry studies; Schäfer TV — experimental procedure, data processing and visualization, developing the experimental model; Rejniuk VL — methodological guidance of gas exchange assessment. All authors contributed to discussion, manuscript writing and editing.

Compliance with the ethical standards: the study was carried out in accordance with the principles of bioethics, approved by the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes.

Received: 2023-09-29 Accepted: 2023-11-20 Published online: 2023-12-07
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  1. Lorenz E, Congdon C, Uphoff D. Modification of acute irradiation injury in mice and guinea-pigs by bone marrow injections. Radiology. 1952; 58 (6): 863–77.
  2. Savchenko VG, redaktor. Protocoly transplantacii allogennyh gemopoetichescih stvolovyh cletok. M.: Praktika, 2020; 320 s.
  3. Pop VP, Rukavicyn OA. Allogeneic hematopoietic stem cell transplantation: prospects and alternatives, own experience. Ros zhurn detsk gematol onkol. 2017; 4 (2): 46–69. Russian.
  4. Keit E, Liveringhouse C, Figura N, Weigand J, Sandoval M, Garcia G, et al. Feasibility and toxicity of full-body volumetric modulated arctherapy technique for high-dose total body irradiation. Technol Cancer Res Treat. 2023; 22: 15330338231180779.
  5. Battipaglia G, Labopin M, Mielke S, Ruggeri A, Zubeyde Nur Ozkurt, Bourhis J, et al. Thiotepa-based regimens are valid alternatives to total-body irradiation-based reduced-intensity conditioning regimens in patients with acute lymphoblastic leukemia: a retrospective study on behalf of the acute leukemia working party of the European society for blood and marrow transplantation. Transplant Cell Ther. 2023; Oct 8: S26666367(23)01582-8. Online ahead of print.
  6. Cahu X, Labopin M, Giebel S, Aljurf M, Kyrcz-Krzemien S, Socié G, et al. Impact of conditioning with TBI in adult patients with T-cell ALL who receive a myeloablative allogenic stem cell transplantation: a report from the acute leukemia working party of EBMT. Bone marrow Transplantation. 2016; 51 (3): 351–7.
  7. Drachyov IS, Zacepin VV, Ivanchenko AV, Ivnitsky JuJu, Kryukov EV, Seleznyov AB. Acute lesions resulting from external irradiation of the human body. In book: Sofronov GA, Kryukov EV, ed. Military toxicology, radiology and medical protection. Saint Petersburg: VMedA, 2023; p. 507–39. Russian.
  8. Konishi T, Ogawa H, Najima Y, Hashimoto S, Wada A, Adachi H, et al. Safety of total body irradiation using intensity-modulated radiation therapy by helical tomotherapy in allogenic hematopoietic stem cell transplantation: a prospective pilot study. J Radiat Res. 2020; 61 (6): 969–76.
  9. Nakagaki M, Kennedy G, Gavin N, Clavarito A, Whitfield K. The incidence of severe oral mucositis in patients undergoing different conditioning regimens in haematopoietic stem cell transplantation. Support Care Cancer. 2022; 30 (11): 9141–9.
  10. Conard RA. Effect of X-irradiation on intestinal motility of the rat. Am J Physiol. 1951; 165 (2): 375–85.
  11. Krantis A, Rana K, Harding R. The effects of γ-radiation on intestinal motor activity and faecal pellet expulsion in the guinea pig. Dig Dis Sci. 1996; 41 (12): 2307–16.
  12. Erickson BA, Otterson MF, Moulder JE, Sarna SK. Altered motility causes the early gastrointestinal toxicity of irradiation. Int J Radiat Oncol. Biol. Phys. 1994; 28 (4): 905–12.
  13. Dorval ED, Mueller GP, Eng RR, Durakovic A, Conclin JJ, Dubois A. Effect of ionizing radiation on gastric secretion and gastric motility in monkeys. Gastroenterology. 1985; 89 (2): 374–80.
  14. Eagle D, Gian V, Lauwers G, Manivel J, Moreb J, Wingard J. Posttransplant complications. Gastroparesis following bone marrow transplantation. Bone Marrow Transplantation. 2001; 28: 59–62.
  15. Chapman MJ, Nguyen NQ, Deane AM. Gastrointestinal dysmotility: clinical consequences and management of the critically ill patient. Gastroenterol Clin North Am. 2011; 40 (4): 725–39.
  16. Patel R, Soni M, Soyantar B, Shivangi S, Satarija S, Saraf M, et al. A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance. Arch Microbiol. 2023. 205 (4): 107.
  17. Annede P, Prieux-Klotz C, Duberge T, Chargari C, Gisserot O, de ́ Jaureguiberry J-P. Radiation induced gastroparesis – case report and literature review. J Gastrointest Oncol. 2017; 8 (4): E52–5.
  18. Vasin MV. The drug B-190 (indralin) in the light of the history of the formation of ideas about the mechanism of action of radioprotectors. Rad Biol Radioecol. 2020; 60 (4): 378–95. Russian.
  19. Kuna P. Chemical radioprotection: Transl. from Czech. M.: Medicina, 1989; p. 192. Russian.
  20. Balahovskij SD, Balahovskij IS. Methods of chemical analysis of blood. 3th ed. M.: Medgiz, 1953; p. 746. Russian.
  21. O’Grady J, Murphy CL, Burry L, Shanahan F, Buckly M. Defining gastrointestinal transit time using video capsule endoscopy: a study of healthy subjects. Endosc Int Open. 2020; 8 (3): E396– E400.
  22. Ivnitsky JuJu, Schäfer TV, Rejniuk VL, Golovko AI. Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications. J Appl Toxicol. 2023; 43 (1): 47–65.
  23. Martynova NA, Gorohova LG. Toxicological evaluation of indole. Bjul. VSNC SO RAMN. 2006; 65 (1): 248–51. Russian.
  24. Sender R, Fuchs S. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016; 14 (8): e1002533.
  25. Tanaka H, Takeuchi K, Okabe S. Role of accumulated gastric content in the pathogenesis of cysteamine- and mepirizole-induced duodenal ulcers in the rat. J Intern Med Suppl. 1990; 732: 69–75.
  26. Mole RH. The effect of X-irradiation on the basal oxygen consumption of the rat. Q J Exp Physiol Cogn Med. Sci. 1953; 38 (2): 69–74.
  27. Russ M, Boerger E, von Platen P, Francis R, Taher M, Boemke W, et al. Surfactant depletioncombined with injurious ventilation results in a reproducible model of the acute respiratory distress syndrome (ARDS). J Vis Exp. 2021; 170: e62327.
  28. Chang J, Liang S, Thanasekaran P, Chang H, Wen L-L, Chen C, et al. Translational medicine in pulmonary-renal crosstalk: therapeutic targeting of p-Cresyl sulfate triggered nonspecific ROS and chemoattractants in dyspneic patients with uremic lung injury. J Clin Med. 2018; 7 (9): 266.
  29. Thome T, Salyers Z, Kumar R, Hang D, Berru F, Ferreira L, et al. Uremic metabolits impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol. 2019; 317 (4): C701–13.
  30. Kim Y-S, Lee H, Lee M, Park Ye, Sehwan M, et al. The effect of mitochondrial transplantation on sepsis depend on the type of cell from which they are isolated. Int J Mol Sci. 2023; 24 (12): 10113.