REVIEW
Molecular genetic studies in the context of biomedical risks for cosmonauts' health
1 Federal State Budgetary Institution “Federal Research and Clinic Center of Space Medicine” of the Federal Biomedical Agency, Moscow, Russia
2 Lomonosov Moscow State University, Moscow, Russia
Correspondence should be addressed: Konstantin V. Latartsev
Shchukinskaya, 5, str. 2, Moscow, 123182, Russia, moc.liamg@vestratal.k
Funding: the study was supported by the RSF grant (project № 22-25-20145 “Exploring the Mechanisms Underlying the Effects of Tolerance to Food Antigens on the Glucose Utilization”.
Author contributions: Latartsev KV — search and analysis of sources, article authoring, editing; Kaspranskiy RR — concept development, article editing.
- Germain A, Kupfer DJ. Circadian rhythm disturbances in depression. Human Psychopharmacology: Clinical and Experimental. 2008; 23 (7): 571–85.
- Johansson C, et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003; 28 (4): 734–9.
- Gotlib IH, et al. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological psychiatry. 2008; 63 (9): 847–51.
- Laje G, et al. Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. American Journal of Psychiatry. 2007; 164 (10): 1530–8.
- Hejjas K, et al. Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2009; 150 (2): 295–9.
- Teper E, O'Brien JT. Vascular factors and depression. International Journal of Geriatric Psychiatry: A journal of the psychiatry of late life and allied sciences. 2008; 23 (10): 993–1000.
- Germain A, Kupfer DJ. Circadian rhythm disturbances in depression. Human Psychopharmacology: Clinical and Experimental. 2008; 23 (7): 571–85.
- Johansson C, et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003; 28 (4): 734–9.
- Goel N, Dinges DF. Predicting risk in space: genetic markers for differential vulnerability to sleep restriction. Acta astronautica. 2012; 77: 207–13.
- Goel N, et al. Circadian rhythms, sleep deprivation, and human performance. Progress in molecular biology and translational science. 2013; 119: 155–90.
- Dickinson D, Elvevåg B. Genes, cognition and brain through a COMT lens. Neuroscience. 2009; 164 (1): 72–87.
- Gaedigk A. Complexities of CYP2D6 gene analysis and interpretation. International review of psychiatry. 2013; 25 (5): 534–53.
- Rudberg I, et al. Impact of the ultrarapid CYP2C19* 17 allele on serum concentration of escitalopram in psychiatric patients. Clinical Pharmacology & Therapeutics. 2008; 83 (2): 322–7.
- Werk AN, Cascorbi I. Functional gene variants of CYP3A. Clinical Pharmacology & Therapeutics. 2014; 96 (3): 340–8.
- Lee KC, Ma JD, Kuo GM. Pharmacogenomics: bridging the gap between science and practice. Journal of the American Pharmacists Association. 2010; 50 (1): e1-e17.
- Lee SH, et al. Association between the 5‐HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder. Psychiatry and clinical neurosciences. 2005; 59 (2): 140–5.
- Helton SG, Lohoff FW. Serotonin pathway polymorphisms and the treatment of major depressive disorder and anxiety disorders. Pharmacogenomics. 2015; 16 (5): 541–53.
- Vijaya Lakshmi SV, et al. Oxidative stress is associated with genetic polymorphisms in one-carbon metabolism in coronary artery disease. Cell biochemistry and biophysics. 2013; 67: 353–61.
- Lin H, et al. Gene-gene interaction analyses for atrial fibrillation. Scientific reports. 2016; 6 (1): 35371.
- Eisenberg DTA, Kuzawa CW, Hayes MG. Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history.American journal of physical anthropology. 2010; 143 (1): 100–11.
- Zwart SR, et al. Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. The FASEB Journal. 2016; 30 (1): 141.
- Glueck CJ, et al. Idiopathic intracranial hypertension, polycysticovary syndrome, and thrombophilia. Journal of Laboratory and Clinical Medicine. 2005; 145 (2): 72–82.
- Thompson D, et al. Cancer risks and mortality in heterozygous ATM mutation carriers. Journal of the National Cancer Institute. 2005; 97 (11): 813–22.
- Yang M, et al. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell stress & chaperones. 2006; 11 (3): 233.
- Konings A, et al. Variations in HSP70 genes associated with noiseinduced hearing loss in two independent populations. European Journal of Human Genetics. 2009; 17 (3): 329–35.
- Villasana L, et al. Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic mice. Radiatsionnaia Biologiia, Radioecologiia. 2008; 48 (2): 167–70.
- Liu CC, et al. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature Reviews Neurology. 2013; 9 (2): 106–18.
- Utkin KV, et al. Ustanovlenie geneticheskikh markerov ustoychivosti i chuvstvitel'nosti cheloveka k radiatsionnomu vozdeystviyu. Immunologiya. 2013; 34 (2): 80–4. Russian.
- Yuan J, et al. Advanced genetic approaches in discovery and characterization of genes involved with osteoporosis in mouse and human. Frontiers in Genetics. 2019; 10: 288.
- Tan LJ, et al. Molecular genetic studies of gene identification for sarcopenia. Human genetics. 2012; 131: 1–31.
- Ralston SH, Uitterlinden AG. Genetics of osteoporosis. Endocrine reviews. 2010; 31 (5): 629–62.
- Judex S, et al. Genetic loci that control the loss and regain of trabecular bone during unloading and reambulation. Journal of Bone and Mineral Research. 2013; 28 (7): 1537–49.
- Shammas MA. Telomeres, lifestyle, cancer, and aging. Current opinion in clinical nutrition and metabolic care. 2011; 14 (1): 28.
- Cawthon RM, et al. Association between telomere length in blood and mortality in people aged 60 years or older. The Lancet. 2003; 361 (9355): 393–5.
- Wu X, et al. Telomere dysfunction: a potential cancer predisposition factor. Journal of the national cancer institute. 2003; 95 (16): 1211–8.
- Epel ES, et al. Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences. 2004; 101 (49): 17312–5.
- Ayouaz A, et al. Telomeres: hallmarks of radiosensitivity. Biochimie. 2008; 90 (1): 60–72.
- Grigorev K, et al. Haplotype diversity and sequence heterogeneity of human telomeres. Genome research. 2021; 31 (7): 1269–79.
- Luxton JJ, et al. Telomere length dynamics and DNA damage responses associated with long-duration spaceflight. Cell Reports. 2020; 33 (10).
- Nishi H, et al. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Molecular and cellular biology. 2004; 24 (13): 6076–83.
- Bezdan D, et al. Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers. Iscience. 2020; 23 (12).
- Snyder MW, et al. Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin. Cell. 2016; 164 (1): 57–68.
- Yoshioka Y, et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nature communications. 2014; 5 (1): 3591.
- Hoshino A, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015; 527 (7578): 329–35.
- Kumar Deshmukh F, et al. The contribution of the 20S proteasome to proteostasis. Biomolecules. 2019; 9 (5): 190.
- Kudriaeva AA, Belogurov AA. Proteasome: a Nanomachinery of Creative Destruction. Biochemistry. 2019; 84: 159–92. Russian.
- Alvarez R, et al. A simulated microgravity environment causes a sustained defect in epithelial barrier function. Scientific reports. 2019; 9 (1): 17531.
- Mencia-Trinchant N, et al. Clonal hematopoiesis before, during, and after human spaceflight. Cell reports. 2020; 33 (10).
- Genovese G, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. New England Journal of Medicine. 2014; 371 (26): 2477–87.
- Pastushkova LKh, et al. Changes in blood proteome of cosmonauts with microand macrovascular injuries due to g-loads at the final stage of long-duration space missions. Aviakosmicheskaya i Ekologicheskaya Meditsina. 2020; 54 (5): 5–14. Russian.
- Kashirina DN, et al. Changes in the Plasma Protein Composition in Astronauts after Space Flight and its Significance for Endothelial Functions. Human Physiology. 2019; 45 (1): 88–96. Russian.
- Morukov VB, et al. Indicators of innate and adaptive immunity of cosmonauts after long-term space flight to international space station. Human Physiology. 2010; 36 (3): 19–30. Russian.
- Rykova MP. Immune system in Russian cosmonauts after orbital space flights. Human Physiology. 2013; 39 (5): 126–126. Russian.
- Novikov VE, et al. Mineral'naya plotnost' kostnoy tkani i molekulyarno-geneticheskie markery ee remodelirovaniya v krovi u kosmonavtov posle dlitel'nykh poletov na mezhdunarodnoy kosmicheskoy stantsii. Human Physiology. 2017; 43 (6): 88–94. Russian.
- Sapetsky AO, et al. Radiation neurobiology of long-term space flights. Biology Bulletin Reviews. 2017; 137 (2): 165–94. Russian.