2024 / 01

Следующая статья
DOI: 10.47183/mes.2024.002

ОБЗОР

Молекулярно-генетическое тестирование в контексте медико-биологических рисков здоровью космонавтов

К. В. Латарцев1,2, Р. Р. Каспранский1,2
Информация об авторах

1 Федеральный научно-клинический центр космической медицины Федерального медико-биологического агентства, Москва, Россия

2 Московский государственный университет имени М. В. Ломоносова, Москва, Россия

Для корреспонденции: Константин Владимирович Латарцев
ул. Щукинская, д. 5, стр. 4, г. Москва, 123182, Россия; moc.liamg@vestratal.k

Информация о статье

Финансирование: обзор выполнен за счет средств, предоставленных для выполнения государственного задания «Изучение состояния здоровья космонавтов, завершивших летную деятельность» (шифр «Долголетие-3»).

Вклад авторов: К. В. Латарцев — поиск и анализ источников, написание текста, редактирование; Р. Р. Каспранский — разработка концепции, редактирование рукописи.

Статья получена: 16.11.2023 Статья принята к печати: 20.12.2023 Опубликовано online: 04.03.2024
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  1. Germain A, Kupfer DJ. Circadian rhythm disturbances in depression. Human Psychopharmacology: Clinical and Experimental. 2008; 23 (7): 571–85.
  2. Johansson C, et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003; 28 (4): 734–9.
  3. Gotlib IH, et al. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological psychiatry. 2008; 63 (9): 847–51.
  4. Laje G, et al. Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. American Journal of Psychiatry. 2007; 164 (10): 1530–8.
  5. Hejjas K, et al. Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2009; 150 (2): 295–9.
  6. Teper E, O'Brien JT. Vascular factors and depression. International Journal of Geriatric Psychiatry: A journal of the psychiatry of late life and allied sciences. 2008; 23 (10): 993–1000.
  7. Germain A, Kupfer DJ. Circadian rhythm disturbances in depression. Human Psychopharmacology: Clinical and Experimental. 2008; 23 (7): 571–85.
  8. Johansson C, et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003; 28 (4): 734–9.
  9. Goel N, Dinges DF. Predicting risk in space: genetic markers for differential vulnerability to sleep restriction. Acta astronautica. 2012; 77: 207–13.
  10. Goel N, et al. Circadian rhythms, sleep deprivation, and human performance. Progress in molecular biology and translational science. 2013; 119: 155–90.
  11. Dickinson D, Elvevåg B. Genes, cognition and brain through a COMT lens. Neuroscience. 2009; 164 (1): 72–87.
  12. Gaedigk A. Complexities of CYP2D6 gene analysis and interpretation. International review of psychiatry. 2013; 25 (5): 534–53.
  13. Rudberg I, et al. Impact of the ultrarapid CYP2C19* 17 allele on serum concentration of escitalopram in psychiatric patients. Clinical Pharmacology & Therapeutics. 2008; 83 (2): 322–7.
  14. Werk AN, Cascorbi I. Functional gene variants of CYP3A. Clinical Pharmacology & Therapeutics. 2014; 96 (3): 340–8.
  15. Lee KC, Ma JD, Kuo GM. Pharmacogenomics: bridging the gap between science and practice. Journal of the American Pharmacists Association. 2010; 50 (1): e1-e17.
  16. Lee SH, et al. Association between the 5‐HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder. Psychiatry and clinical neurosciences. 2005; 59 (2): 140–5.
  17. Helton SG, Lohoff FW. Serotonin pathway polymorphisms and the treatment of major depressive disorder and anxiety disorders. Pharmacogenomics. 2015; 16 (5): 541–53.
  18. Vijaya Lakshmi SV, et al. Oxidative stress is associated with genetic polymorphisms in one-carbon metabolism in coronary artery disease. Cell biochemistry and biophysics. 2013; 67: 353–61.
  19. Lin H, et al. Gene-gene interaction analyses for atrial fibrillation. Scientific reports. 2016; 6 (1): 35371.
  20. Eisenberg DTA, Kuzawa CW, Hayes MG. Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history.American journal of physical anthropology. 2010; 143 (1): 100–11.
  21. Zwart SR, et al. Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. The FASEB Journal. 2016; 30 (1): 141.
  22. Glueck CJ, et al. Idiopathic intracranial hypertension, polycysticovary syndrome, and thrombophilia. Journal of Laboratory and Clinical Medicine. 2005; 145 (2): 72–82.
  23. Thompson D, et al. Cancer risks and mortality in heterozygous ATM mutation carriers. Journal of the National Cancer Institute. 2005; 97 (11): 813–22.
  24. Yang M, et al. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell stress & chaperones. 2006; 11 (3): 233.
  25. Konings A, et al. Variations in HSP70 genes associated with noiseinduced hearing loss in two independent populations. European Journal of Human Genetics. 2009; 17 (3): 329–35.
  26. Villasana L, et al. Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic mice. Radiatsionnaia Biologiia, Radioecologiia. 2008; 48 (2): 167–70.
  27. Liu CC, et al. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature Reviews Neurology. 2013; 9 (2): 106–18.
  28. Уткин К. В. и др. Установление генетических маркеров устойчивости и чувствительности человека к радиационному воздействию. Иммунология. 2013; 34 (2): 80–4.
  29. Yuan J, et al. Advanced genetic approaches in discovery and characterization of genes involved with osteoporosis in mouse and human. Frontiers in Genetics. 2019; 10: 288.
  30. Tan LJ, et al. Molecular genetic studies of gene identification for sarcopenia. Human genetics. 2012; 131: 1–31.
  31. Ralston SH, Uitterlinden AG. Genetics of osteoporosis. Endocrine reviews. 2010; 31 (5): 629–62.
  32. Judex S, et al. Genetic loci that control the loss and regain of trabecular bone during unloading and reambulation. Journal of Bone and Mineral Research. 2013; 28 (7): 1537–49.
  33. Shammas MA. Telomeres, lifestyle, cancer, and aging. Current opinion in clinical nutrition and metabolic care. 2011; 14 (1): 28.
  34. Cawthon RM, et al. Association between telomere length in blood and mortality in people aged 60 years or older. The Lancet. 2003; 361 (9355): 393–5.
  35. Wu X, et al. Telomere dysfunction: a potential cancer predisposition factor. Journal of the national cancer institute. 2003; 95 (16): 1211–8.
  36. Epel ES, et al. Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences. 2004; 101 (49): 17312–5.
  37. Ayouaz A, et al. Telomeres: hallmarks of radiosensitivity. Biochimie. 2008; 90 (1): 60–72.
  38. Grigorev K, et al. Haplotype diversity and sequence heterogeneity of human telomeres. Genome research. 2021; 31 (7): 1269–79.
  39. Luxton JJ, et al. Telomere length dynamics and DNA damage responses associated with long-duration spaceflight. Cell Reports. 2020; 33 (10).
  40. Nishi H, et al. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Molecular and cellular biology. 2004; 24 (13): 6076–83.
  41. Bezdan D, et al. Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers. Iscience. 2020; 23 (12).
  42. Snyder MW, et al. Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin. Cell. 2016; 164 (1): 57–68.
  43. Yoshioka Y, et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nature communications. 2014; 5 (1): 3591.
  44. Hoshino A, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015; 527 (7578): 329–35.
  45. Kumar Deshmukh F, et al. The contribution of the 20S proteasome to proteostasis. Biomolecules. 2019; 9 (5): 190.
  46. Кудряева А. А., Белогуров А. А. Протеасома: наномашинерия созидательного разрушения. Биохимия. 2019; 84: 159–92.
  47. Alvarez R, et al. A simulated microgravity environment causes a sustained defect in epithelial barrier function. Scientific reports. 2019; 9 (1): 17531.
  48. Mencia-Trinchant N, et al. Clonal hematopoiesis before, during, and after human spaceflight. Cell reports. 2020; 33 (10).
  49. Genovese G, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. New England Journal of Medicine. 2014; 371 (26): 2477–87.
  50. Пастушкова Л. Х. и др. Изменения протеома крови космонавтов с микро- и макрососудистыми травмами при перегрузках на заключительном этапе длительных космических полетов. Авиакосмическая и экологическая медицина. 2020; 54 (5): 5–14.
  51. Каширина Д. Н. и др. Изменение белкового состава плазмы космонавтов после космического полета и его значение для функций эндотелия. Физиология человека. 2019; 45 (1): 88–96.
  52. Моруков Б. В. и др. Показатели врожденного и адаптивного иммунитета у космонавтов после длительных космических полетов на Международной космической станции. Физиология человека. 2010; 36 (3): 19–30.
  53. Рыкова М. П. Иммунная система у российских космонавтов после орбитальных полетов. Физиология человека. 2013; 39 (5): 126–126.
  54. Новиков В. Е. и др. Минеральная плотность костной ткани и молекулярно-генетические маркеры ее ремоделирования в крови у космонавтов после длительных полетов на международной космической станции. Физиология человека. 2017; 43 (6): 88–94.
  55. Сапецкий А. О. и др. Радиационная нейробиология дальних космических полетов. Успехи современной биологии. 2017; 137 (2): 165–94.