ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Antioxidant effects of the synthetic thyronamine analogue in experimental cerebral ischemia
About authors
1 V.K. Gusak Institute of Emergency and Reconstructive Surgery, Donetsk, Russia
2 Joint Institute for Nuclear Research, Dubna, Russia
Correspondence should be addressed: Dmitry A. Filimonov
Leninsky Prospekt, 47, Donetsk, 283045, Russia; ur.xednay@umnd.oruen
About paper
Funding: the study was carried out within the framework of the state assignment of the Ministry of Health of the Russian Federation № 1023042500162-83.1.4;3.2.25 (2023–2025).
Author contribution: Filimonov DA — core concept, general management, constructing the statistical model, data processing; Eresko AB, Raksha EV — data acquisition, literature review, Т0АМ synthetic analogue preparation and spectroscopic analysis; Trubnikova NN — design of the experiment on ischemia simulation, experimental procedure, data acquisition, manuscript writing; Ischenko RV — general management, data acquisition, manuscript editing; Tereschenko DA — biochemical tests, data acquisition, manuscript draft editing; Kisilenko IA — animal experiments, manuscript writing and editing; Nosova IN — data acquisition and processing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the V.K. Gusak Institute of Emergency and Reconstructive Surgery (protocol No 3 dated 23 November 2023).
Received: 2024-01-04
Accepted: 2024-02-04
Published online: 2024-03-22
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Fig. The oxidative stress marker activity in the brain of model rats with acute hemispheric ischemia. TBA-AP — concentration of products actively reacting with thiobarbituric acid; SOD — superoxide dismutase; GPx — glutathione peroxidase
Table. The antioxidant protection indicators in the brain tissue of model rats with acute hemispheric ischemia (SOD, GPx and TBA-AP levels are provided per 1 mg of protein)
