Funding: the study was carried out within the framework of the state assignment of the Ministry of Health of the Russian Federation № 1023042500162-83.1.4;3.2.25 (2023–2025).

Author contribution: Filimonov DA — core concept, general management, constructing the statistical model, data processing; Eresko AB, Raksha EV — data acquisition, literature review, Т0АМ synthetic analogue preparation and spectroscopic analysis; Trubnikova NN — design of the experiment on ischemia simulation, experimental procedure, data acquisition, manuscript writing; Ischenko RV — general management, data acquisition, manuscript editing; Tereschenko DA — biochemical tests, data acquisition, manuscript draft editing; Kisilenko IA — animal experiments, manuscript writing and editing; Nosova IN — data acquisition and processing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the V.K. Gusak Institute of Emergency and Reconstructive Surgery (protocol No 3 dated 23 November 2023).