ORIGINAL RESEARCH

Combined matrices and tissue-engineered constructs made of biopolymers in reconstructive surgery of ENT organs

Daykhes NA1, Diab KhM1, Nazaryan DN1, Vinogradov VV1, Reshulskiy SS1, Machalov AS1, Karshieva SSh2, Zhirnov SV2,3, Osidak EO4, Kovalev AV5, Hesuani YuD6
About authors

1 National Medical Research Center for Otorhinolaryngology of the Federal Medical Biological Agency, Moscow, Russia

2 National University of Science and Technology MISIS, Moscow, Russia

3 TrioNova LLC, Moscow, Russia

4 Imtek LLC, Moscow, Russia

5 Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russia

6 3D Bioprinting Solutions, Moscow, Russia

Correspondence should be addressed: Sergey S. Reshulsky
Volokolamskoe shosse, 30/2, Moscow, 123182, Russia; ur.liam@50SSR

About paper

Author contributions: Daikhes NA — concept, planning the experiment, management, manuscript editing; Diab KhM — manuscript writing, data provosion; Nazaryan DN — surgical stage of the experiment, manuscript editing; Vinogradov VV, Reshulsky SS — manuscript writing, data acquisition; Machalov AS — planning the experiment, data acquisition, manuscript editing; Karshieva SSh — creating the endoprosthesis, cell culture maintenance; Zhirnov SV — creating the endoprosthesis, printing the substrate; Osidak EO — creating the endoprosthesis, developing the hydrogel; Kovalev AV — histological assessment; Hesuani YuD — creating the resulting tissue-engineered construct.

Соблюдение этических стандартов: все манипуляции с животными были проведены в соответствии c едиными этическими нормами Базельской декларации.

Received: 2023-12-20 Accepted: 2024-02-14 Published online: 2024-03-25
|
  1. Cabrejo R, Persing J, Alperovich M. Epidemiologic assessment of microtia in over 23 million consecutive United States births. J Craniofac Surg. 2019; 30: 342–6.
  2. Gautam R, Kumar J, Pradhan GS, Passey JC, Meher R, Mehndiratta A. High-resolution computed tomography evaluation of congenital aural atresia — how useful is this? J Laryngol Otol. 2020; 134 (7): 610–22. DOI: 10.1017/S002221512000136X. Epub 2020 Jul 20.
  3. Andrews J, Kopacz AA, Hohman MH. Ear Microtia In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023; 2023 Mar 1. Available from: https://pubmed.ncbi.nlm.nih.gov/33085390/.
  4. Hartzell LD, Sivakumar Chinnadurai. Microtia and related facial anomalies. Clin Perinatol. 2018; 45 (4): 679–97. DOI: 10.1016/j.clp.2018.07.007. Epub 2018 Sep 18.
  5. Veugen CCAFM, Dikkers FG, de Bakker BS. The Developmental Origin of the Auricula Revisited. Laryngoscope. 2020; 130 (10): 2467–74.
  6. Daikhes NA, Vinogradov VV, Reshulskiy SS. Hirurgicheskaja reabilitacija i profilaktika oslozhnenij pri lechenii pacientov s zlokachestvennymi opuholjami gortani: uchebnoe posobie. M.: RITM, 2023; 196 s. Russian.
  7. Daikhes NA, Vinogradov VV, Reshulskiy SS, i dr. Posobie dlja pacientov, perenesshih laringjektomi. Nacional'nyj medicinskij issledovatel'skij centr otorinolaringologii Federal'nogo mediko-biologicheskogo agentstva. Moskva, 2021; 98 s. Dostupno po ssylke: https://rusneb.ru/catalog/000199_000009_010732133/?ysclid=ltxas6vey4545118904. Russian.
  8. Stuzin JM, Rohrich RJ. Plastic and reconstructive surgery and the evolution of cosmetic surgery education. Plast Reconstr Surg. 2021; 147 (3): 783–8. DOI: 10.1097/PRS.0000000000007697.
  9. Zhang TY, Bulstrode N, Chang KW, Cho YS, Frenzel H, Jiang D, et al. International Consensus Recommendations on Microtia, Aural Atresia and Functional Ear Reconstruction. J Int Adv Otol. 2019; 15 (2): 204–8. DOI: 10.5152/iao.2019.7383. PMID: 31418720; PMCID: PMC6750779
  10. Zhou G, et al. In vitro regeneration of patient-specific earshaper cartilage and its first clinical application for auricular reconstruction. E Bio Medicine. 2018; 28: 287–302. DOI: 10.1016/j.ebiom.2018.01.011. Epub 2018 Jan 13. PMID: 293962297; PMCID5835555.
  11. Diab HMA, Nazarjan DN, Daikhes NA, i dr. Mezhdisciplinarnyj podhod k reabilitacii pacientov s vrozhdennoj atreziej naruzhnogo sluhovogo prohoda i mikrotiej. Vestnik otorinolaringologii. 2018; 2: 17–21.
  12. Diab HMA, Nazarjan DN, Dajhes NA, i dr. Ustranenie vrozhdennoj atrezii naruzhnogo sluhovogo prohoda s odnomomentnym jektoprotezirovaniem ushnoj rakoviny. Vestnik Klinicheskoj Bol'nicy # 51. 2017; 1: 18–19. Russian.
  13. Daikhes NA, Nazarjan DN, Gileva KS, i dr. Perekrestnaja peresadka kombinirovannogo licevogo transplantata v jeksperimente na bioob"ektah. Medicina jekstremal'nyh situacij. 2020; 4: 24–30. Russian.
  14. Egorihina MN, Muhina PA, Bronnikova II. Skaffoldy kak sistemy dostavki biologicheski aktivnyh i lekarstvennyh veshhestv. Kompleksnye problemy serdechno-sosudistyh zabolevanij. 2020; 9 (1): 92–102. DOI: 10.17802/2306-1278-2020-9-1-92-102. Russian.
  15. Daikhes NA, Vinogradov VV, Reshulskiy SS, i dr. Onkologicheskaja patologija v praktike vracha-otorinolaringologa. M.: GJeOTAR-Media, 2021; 141 s. Russian.
  16. Trofimov EI, Vinogradov VV, Marchenko MG. Osobennosti zazhivlenija ran pri hirurgicheskom lechenii bol'nyh rakom gortani i gortanogolotki. Onkohirurgija. 2011; 3 (4): 13–16. Russian.
  17. Svistushkin MV, Bakulina SV, Starostina AA, i dr. Primenenie mezenhimal'nyh stromal'nyh kletok cheloveka v rekonstrukcii golosovyh skladok. Gen i Kletki. 2022; 17 (3): 25. Russian.
  18. Borrelli MR, Hu MS, Longaker MT, Lorenz HP. Tissue engineering and regenerative medicine in craniofacial reconstruction and facial aesthetics. J Craniofac Surg. 2020; 31: 15–27.
  19. Eltom A, Zhong G, Muhammad A. Scaffold techniques and designs in tissue engineering functions and purposes: a review. Adv Mater Sci Eng. 2019; 2019: 1–13. DOI: 10.1155/2019/3429527.
  20. Shehter AB, Guller AE, Istranov LP, i dr. Morfologija kollagenovyh matriksov dlja tkanevoj inzhenerii v urologii (biosovmestimost', biodegradacija, tkanevaja reakcija). Arhiv patologii. 2015; 6: 29– 38. Russian.
  21. Hamilton NJ, Kanani M, Roebuck DJ, et al. Tissue-engineered tracheal replacement in a child: a 4-year follow-up study. Am J Transplant. 2015; 15 (10): 2750–7. Available from: https://doi.org/10.1111/ajt.13318.
  22. Zurina M, Presniakova VS, Butnaru DV, Svistunov AA, Timashev PS, Rochev YA. Tissue engineering using a combined cell sheet technology and scaffolding approach. Acta Biomaterialia. 2020; 111: 63–83. Available from: https://doi.org/10.1016/j.actbio.2020.06.016.