2024 / 02

Next Paper
DOI: 10.47183/mes.2024.026

ORIGINAL RESEARCH

Method to assess the effects of bioactive compounds solutions on blood clotting

Manuvera VA1,2, Brovina KA1,2, Bobrovsky PA1,2, Grafskaia EN1, Kharlampieva DD1, Lazarev VN1,2
About authors

1 Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency, Moscow, Russia

2 Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow Region, Russia

Correspondence should be addressed: Valentin A. Manuvera
Malaya Pirogovskaya, 1A, Moscow, 119435, Russia; ur.xednay@arevunamv

About paper

Funding: the study was supported by the Russian Science Foundation grant No. 23-25-00006, https://rscf.ru/project/23-25-00006/.

Author contribution: Manuvera VA — concept, experiments, manuscript writing; Brovina KA — experiments, manuscript editing; Bobrovsky PA — data analysis, visualization, manuscript editing; Grafskaia EN — experiments, manuscript editing; Kharlampieva DD — experiments, manuscript editing; Lazarev VN — research team management, manuscript editing.

Received: 2024-03-27 Accepted: 2024-06-15 Published online: 2024-06-28
|
  1. Barkagan ZS. Diagnostika i kontroliruemaja terapija narushenij gemostaza. Moskva: OOO "Mediko-tehnologicheskoe predprijatie «N'judiamed», 2008; 292 s. Russian.
  2. Winter W, Flax S, Harris N. Coagulation testing in the core laboratory. Laboratory Medicine. 2017; 48 (4): 295–313. Available from: https://doi.org/10.1093/labmed/.
  3. Makarov VA, Spasov AA, Plotnikov MB, Belozerskaja GG, Vasileva TM, Drozd NN, i dr. Metodicheskie rekomendacii po izucheniju lekarstvennyh sredstv, vlijajushhih na gemostaz. V knige: Mironov AN, Bunjatjan ND, Vasil'ev AN, Verstakova OL, Zhuravleva MV, Lepahin VK, i dr, redaktory. Rukovodstvo po provedeniju doklinicheskih issledovanij lekarstvennyh sredstv. Chast' pervaja. M.: Grif i K, 2012; s. 453–479. Russian.
  4. Manuvera VA, Kharlampieva DD, Bobrovsky PA, Grafskaia EN, Brovina KA, Lazarev VN. New anticoagulant protein from medicinal leech. Biochemical and Biophysical Research Communications. 2024; 696: 149473. Available from: https://doi.org/10.1016/j.bbrc.2024.149473
  5. Nutt EM, Jain D, Lenny AB, Schaffer L, Siegl PK, Dunwiddie CT, Purification and characterization of recombinant antistasin: a leech-derived inhibitor of coagulation factor Xa, Arch Biochem Biophys. 1991; 285: 37–44. Available from: https://doi.org/10.1016/0003-9861(91)90325-D.
  6. Müller C, Mescke K, Liebig S, et al. More than just one: multiplicity of Hirudins and Hirudin-like Factors in the Medicinal Leech, Hirudo medicinalis. Mol Genet Genomics. 2016; 291: 227–240. Available from: https://doi.org/10.1007/s00438-015-1100-0.
  7. Onishi A, St Ange K, Dordick JS, Linhardt RJ. Heparin and anticoagulation. Front Biosci Landmark Ed. 2016; 21 (7): 1372– 92. Available from: https://doi.org/10.2741/4462.