ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Comparative assessment of toxic pulmonary edema caused by poisoning with carbonyl chloride and fluoroplastic thermal degradation products
About authors
1 Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, Saint-Petersburg, Russia
2 State Scientific Research Test Institute of the Military Medicine of Defense Ministry of the Russian Federation, Saint-Petersburg, Russia
Correspondence should be addressed: Dmitry M. Yaroshenko
Akademika Lebedeva, 6, Saint-Petersburg, 194044, Russia; ur.xednay@bps-oknehsoray
About paper
Author contribution: Yaroshenko DM — experimental part of the study, processing of experimental study results, manuscript writing; Lopatko VS — literature review, technical data processing, manuscript writing; Tolkach PG — interpretation of the results, manuscript writing; Vengerovich NG — interpretation of the results, manuscript editing; Basharin VA — research concept, determining the main directions of the study, manuscript editing.
Compliance with the ethical standards: the study was approved by the Ethics Committee of the Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation (protocol No. 288 dated 20 February 2024). The research procedure was guided by the requirements of the regulatory legal acts on conducting animal experiments, including humane handling of animals (Directive 2010/63/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes).
Received: 2024-03-15
Accepted: 2024-06-12
Published online: 2024-06-28
|
Fig. 1. Dynamic changes in the rat lung/body ratio after the exposure to carbonyl chloride and fluoroplastic thermal degradation products (relative units (Me [Q1; Q3]). * — significant differences from controls; six animals per group
Fig. 2. Histological changes in the rat lung tissues 3 and 6 h after the exposure to carbonyl chloride and fluoroplastic thermal degradation products (hematoxylin and eosin, 50× magnification). А. Control. B. Poisoning 1 (carbonyl chloride), 3 h. C. Poisoning 2 (fluoroplastic thermal degradation products), 3 h. D. Poisoning 1 (carbonyl chloride), 6 h. E. Poisoning 2 (fluoroplastic thermal degradation products), 6 h
Fig. 3. Dynamic changes in the rat arterial blood partial pressure of oxygen (left) and carbon dioxide (right) at different times after the exposure to carbonyl chloride
and fluoroplastic thermal degradation products (mm Hg (Me)). p < 0.05 — significant differences from the groups Poisoning 1 (carbonyl chloride) and Poisoning 2
(fluoroplastic thermal degradation products)
