ORIGINAL RESEARCH

Comparative assessment of toxic pulmonary edema caused by poisoning with carbonyl chloride and fluoroplastic thermal degradation products

Yaroshenko DM1, Lopatko VS1, Tolkach PG1, Vengerovich NG2, Basharin VA1
About authors

1 Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, Saint-Petersburg, Russia

2 State Scientific Research Test Institute of the Military Medicine of Defense Ministry of the Russian Federation, Saint-Petersburg, Russia

Correspondence should be addressed: Dmitry M. Yaroshenko
Akademika Lebedeva, 6, Saint-Petersburg, 194044, Russia; ur.xednay@bps-oknehsoray

About paper

Author contribution: Yaroshenko DM — experimental part of the study, processing of experimental study results, manuscript writing; Lopatko VS — literature review, technical data processing, manuscript writing; Tolkach PG — interpretation of the results, manuscript writing; Vengerovich NG — interpretation of the results, manuscript editing; Basharin VA — research concept, determining the main directions of the study, manuscript editing.

Compliance with the ethical standards: the study was approved by the Ethics Committee of the Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation (protocol No. 288 dated 20 February 2024). The research procedure was guided by the requirements of the regulatory legal acts on conducting animal experiments, including humane handling of animals (Directive 2010/63/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes).

Received: 2024-03-15 Accepted: 2024-06-12 Published online: 2024-06-28
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  1. Cao C, Zhang L, Shen J. Phosgene-induced acute lung injury: approaches for mechanism-based treatment strategies. Front Immunol. 2022; (13): 917395.
  2. Patocka J. Perfluoroisobutene: poisonous choking gas. Mil Med Sci Lett (Voj Zdrav Listy). 2019; 883): 98–105.
  3. Lu Q, Huang S, Meng X, Zhang J, Yu S, Li J, et al. Mechanism of phosgene-induced acute lung injury and treatment strategy. Int J Mol Sci. 2021; 22 (20): 10933.
  4. Muir B, Cooper DB, Carrick WA, Timperley CM, Slater BJ, Quick S. Analysis of chemical warfare agents III. Use of bis-nucleophiles in the trace level determination of phosgene and perfluoroisobutylene. J Chromatogr A. 2005; 1098 (1-2): 156–65.
  5. Marzec J, Nadadur S. Countermeasures against pulmonary threat agents. J Pharmacol Exp Ther. 2024; 388 (2): 560–7.
  6. Bezmakova AL, Potapova AV, Judin MA, Chepur SV, Shefer TV. Iz istorii ispol'zovanija himicheskogo oruzhija kak instrumenta diversifikacii voenno-politicheskogo vlijanija. Voenno-medicinskij zhurnal. 2023; 344 (11): 68–74. Russian.
  7. Mistry S, Scott TE, Jugg B, Perrott R, Saffaran S, Bates DG. An in-silico porcine model of phosgene-induced lung injury predicts clinically relevant benefits from application of continuous positive airway pressure up to 8 h post exposure. Toxicol Lett. 2024; (391): 45–54.
  8. Zhang XD, Yu WH, Liu MM, Liu R, Wu H, Wang Z, et al. Pentoxifylline inhibits phosgene-induced lung injury via improving hypoxia. Drug Chem Toxicol. 2023; 46 (6): 1100–7.
  9. Panshin JuA, Malkevich SG, Dunaevskaja CS. Ftoroplasty. L.: Himija, 1978. 232 p. Russian.
  10. Tolkach PG, Basharin VA, Sizova DT, Chajkina MA, Lopatko VS. Kamera termookislitel'noj destrukcii dlja ocenki pokazatelja toksichnosti produktov gorenija. Patent RU2791221С1. 3.06.2023.
  11. Zobnin JuV, redaktor. Otravlenie monooksidom ugleroda (ugarnym gazom). SPb.: Taktik-Studio, 2011; 86 p. Russian.
  12. Moroz VV, Golubev AM, Kuzovlev AN. Otek legkih: klassifikacija, mehanizmy razvitija, diagnostika. Obshhaja reanimatologija. 2009; (1): 83–8. Russian.