ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
The effect of high concentrations of fentanyl on an isolated heart of rat
About authors
Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, Leningrad region, Russia
Correspondence should be addressed: Olga V. Nechaykina
Zavodskaya, 6/2, k. 93, gp Kuzmolovsky, Kuzmolovskoye g. p., Vsevolozhsky r-n, Leningradskaya oblast, 188663, ur.liam@8722aglo
About paper
Author contributions: Nechaykina OV — study conceptualization and design, data collection, data processing, article authoring; Laptev DS — study conceptualization and design, data collection, data processing, article editing; Bobkov DV — data processing, article editing; Petunov SG — data processing and interpretation, general guidance; Radilov AD — data processing and interpretation.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Institute of Hygiene, Occupational Pathology and Human Ecology (Minutes #3 of July 21, 2022), and executed in compliance with the bioethics rules approved by the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes. The animals were kept in accordance with GOST 33215-2014 Laboratory Animals Keeping Guidelines (edition of 2016).
Received: 2024-03-06
Accepted: 2024-06-08
Published online: 2024-06-26
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Table 1. Parameters of contractile activity of the isolated heart of white rats under the action of fentanyl. The data are percentage relative to the background (M ± SE)
Note: * — statistically significant difference from the control at p < 0.05; n — number of observations; PerP — perfusion pressure; Int1min — integral indicator of heart contractility per minute; PP — pulse pressure; +dP/dt and –dP/dt — first time derivative of pressure; EDP — end diastolic pressure.
Table 2. Parameters of ECG of the isolated heart of white rats under the action of fentanyl. The data are in absolute values (M ± SE)
Note: * — statistically significant difference from control at p < 0.05.
