ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Evaluation of anti-radiation efficacy of the Staphylococcus aureus-derived therapeutic agent
About authors
1 Federal Center for Toxicological, Radiation, and Biological Safety, Kazan, Russia
2 Kazan Federal University, Kazan, Russia
3 Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russia
4 Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia
5 Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan, Russia
6 Academy of Sciences of the Republic of Tatarstan, Kazan, Russia
Correspondence should be addressed: Timur R. Gaynutdinov
Nauchnyj Gorodok, 2, Kazan, 420075, Russia; ur.liam@rumit_rtg
About paper
Funding: the study was conducted the expense of the subsidy granted to the Federal Center for Toxicological, Radiation, and Biological Safety for research work, state registration No. 01200202604.
Acknowledgements: the study was performed within the framework of the Strategic Academic Leadership Program of the Kazan Federal University (PRIORITY-2030).
Author contribution: Gaynutdinov TR — literature review on the issue, conducting the experimental part of the study, processing of the data acquired, text editing, manuscript preparation; Ryzhkin SA — academic advising; Shavaliev RF — advisory assistance during the experimental part of the study, text editing; Vagin KN, Kurbangaleev YaM, Ohrimenko SE — advisory assistance during the study; Kalimullin FH — assistance and conducting the experimental part of the study; Plotnikova EM, Idrisov AM, Mayorova EN — conducting the experiments, statistical data processing.
Compliance with ethical standards: all the procedures involving model animals were conducted in accordance with the Good Laboratory Practice and the Directive 2010/63/EU of the European Parliament and of the Council (2010) on the protection of animals used for scientific purposes.
Received: 2024-05-10
Accepted: 2024-06-08
Published online: 2024-06-26
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Table 1. Survival of the lethally exposed white mice against the background of using the test St. аureus st. 209 variants 3 days after the single subcutaneous injection of the therapeutic agent, n = 9
Note: m. c. — microbial cells; st. — strain; exp. — exposed.
Table 2. Results of the radiotoxin indication in the Staphylococcus аureus st. 209 variants exposed to various gamma radiation doses
Note: st. — strain; exp. — exposed.
Table 3. Peroxidase activity of the cells of the original and radioresistant St. aureus st. 209 cultures
Note: ×× — p < 0.01; ××× — p < 0.001; st. — strain.
Table 4. Blood indicators of white mice on day 10 after the exposure and single subcutaneous injection of St. aureus st. 209R70, n = 10
Note: ×× — p < 0.01; ××× — p < 0.001; st. — strain.
Table 5. Concentrations of malondialdehyde (MDA) and interleukin 1β in blood serum and bone marrow of the lethally irradiated white mice treated with St. aureus 209R70 8 days after the exposure and treatment, n = 10
Note: ×× — p < 0.01; ××× — p < 0.001.
