2024 / 02

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DOI: 10.47183/mes.2024.023

ORIGINAL RESEARCH

Evaluation of anti-radiation efficacy of the Staphylococcus aureus-derived therapeutic agent

Gaynutdinov TR1,2,3, Ryzhkin SA2,3,4,6, Shavaliev RF4,5, Vagin KN1,2, Kurbangaleev YaM1, Kalimullin FH1, Plotnikova EM1, Idrisov AM1, Ohrimenko SE3, Mayorova EN1
About authors

1 Federal Center for Toxicological, Radiation, and Biological Safety, Kazan, Russia

2 Kazan Federal University, Kazan, Russia

3 Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Moscow, Russia

4 Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia

5 Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan, Russia

6 Academy of Sciences of the Republic of Tatarstan, Kazan, Russia

Correspondence should be addressed: Timur R. Gaynutdinov
Nauchnyj Gorodok, 2, Kazan, 420075, Russia; ur.liam@rumit_rtg

About paper

Funding: the study was conducted the expense of the subsidy granted to the Federal Center for Toxicological, Radiation, and Biological Safety for research work, state registration No. 01200202604.

Acknowledgements: the study was performed within the framework of the Strategic Academic Leadership Program of the Kazan Federal University (PRIORITY-2030).

Author contribution: Gaynutdinov TR — literature review on the issue, conducting the experimental part of the study, processing of the data acquired, text editing, manuscript preparation; Ryzhkin SA — academic advising; Shavaliev RF — advisory assistance during the experimental part of the study, text editing; Vagin KN, Kurbangaleev YaM, Ohrimenko SE — advisory assistance during the study; Kalimullin FH — assistance and conducting the experimental part of the study; Plotnikova EM, Idrisov AM, Mayorova EN — conducting the experiments, statistical data processing.

Compliance with ethical standards: all the procedures involving model animals were conducted in accordance with the Good Laboratory Practice and the Directive 2010/63/EU of the European Parliament and of the Council (2010) on the protection of animals used for scientific purposes.

Received: 2024-05-10 Accepted: 2024-06-08 Published online: 2024-06-26
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  1. de Cassan D, Hoheisel AL, Glasmacher B. Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats. J Mater Sci: Mater Med. 2019; 30: 42. DOI: 10.1007/s10856-019-6245-7.
  2. Tapia-Guerrero YS, Del Prado-Audelo ML, Borbolla-Jiménez FV, Gomez D, García-Aguirre I, Colín-Castro CA, et al. Effect of UV and Gamma Irradiation Sterilization Processes in the Properties of Different Polymeric Nanoparticles for Biomedical Applications. Materials (Basel, Switzerland). 2020; 13 (5): 1090. DOI: 10.3390/ma13051090.
  3. Shehata MM, Gomaa FA, Helal Z. Effects of gamma and electron beam irradiation on viability and DNA elimination of Staphylococcus aureus. Archives of Clinical Microbiology. 2011; 121: 44–55. DOI: 10:3823/244.
  4. Xu Y, Chen Y, Liu H, Lei X, Guo J, Cao K, et al. Heat-killed salmonella typhimurium (HKST) protects mice against radiation in TLR4-dependent manner. Oncotarget. 2017; 40 (8): 67082–93. DOI: 10.18632/oncotarget.17859.
  5. Tobin GJ, Tobin JK, Gaidamakova EK, Wiggins TJ, Bushnell RV, Lee WM, et al. A novel gamma radiation-inactivated sabin-based polio vaccine. PloS one. 2020; 15 (1): e0228006. DOI: 10.1371/journal.pone.0228006.
  6. Mullbacher A, Pardo J, Furuya Y. SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell Immunity. Pathogens (Basel, Switzerland). 2020; 9 (11): 928. DOI: 10.3390/pathogens9110928.
  7. Bruno-Barcena JM, Azcárate-Peril AM, Hassan HM. Role of antioxidant enzymes in bacterial resistance to organic acids. Applied and Euvironuental Microbiology. 2010: 76 (9): 2747–50. DOI: 10.1128/AEM.02718-09.
  8. Mun GI, Kim S, Choi E, Kim CS, Lee YS. Pharmacology of natural radioprotectors. Archives of pharmacal research. 2018; 41 (11): 1033–50. DOI: 10.1007/s12272-018-1083-6.
  9. Montoro A. Radioprotection and Radiomitigation: From the Bench to Clinical Practice. Biomedicines. 2020; 8 (11): 461. DOI: 10.3390/biomedicines8110461.
  10. ГGaynutdinov TR. Evaluation of the anti-radiation effectiveness of drugs derived from substances of microbial origin. Veterinarny Vrach. 2024; 1: 52–7. DOI: 10.33632/1998-698X_2024_1_52. Russian.
  11. Riehl TE, Alvarado D, Ee X, Zuckerman A, Foster L, Kapoor V, et al. Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells. Gut. 2019; 68 (6): 1003–13. DOI: 10.1136/gutjnl-2018-316226.
  12. Gaynutdinov TR, Nizamov RN, Idrisov AM, Rakhmatullina GI, Guryanova VA. Obtaining radioactivated strains of microorganisms and studying their antiradiation efficiency IOP Conf. Series: Earth and Environmental Science. 2021; 723: 042008. DOI: 10.1088/1755-1315/723/4/042008.
  13. Ivanov АА, Simbircev AS, Maltsev VN, Petrov LN, Andrianova IE, Stavrakova NM, et al. Lowering risck of being a carrier of opportunistic infections in case of radiation damage by using probiotic vitaflor and antibiotics. Extreme medicine. 2013; 1 (43): 76–81. Russian.
  14. Kobatov AI, Verbitskaya NB, Polotsky AE, Savin II, Grebenyuk AN. Development of a technology for producing a fermented milk product on space shipboard and evaluation of its probiotic and potential radioprotective properties. Extreme medicine. 2019; 21 (4): 517–26. Russian.
  15. Kobatov AI, Polyntsev DG, Savin II, Popova EV, Kutnik IV. The «Probiovit» Space Experiment: Outputs and Outlook (Part 1). Manned Spaceflight. 2023; 1 (46): 74–87. Russian.
  16. Kobatov AI, Polyntsev DG, Savin II, Popova EV, Kutnik IV. The «Probiovit» Space Experiment: Outputs and Outlook (Part 2). Manned Spaceflight. 2023; 2 (47): 87–98. Russian.
  17. Chance B, Sies H, Boveris A. Hydroperoxide methabolism in mammalian organs. Physiol Rev. 1979; 59 (3): 527–605. DOI: 10.1152/physrev.1979.59.3.527.
  18. Mathialagan N, Roberts RM. A role for cytokines in early pregnancy. Indian J. Physiol Pharmacol. 1994; 38: 153–62. PubMed PMID: 7814074.
  19. Guryanova VA, Tarasova NB. Lipid peroxygenation at liver injury by ionizing radiation. Academic notes of Kazan state academy of veterinary medicine named after N. Bauman. 2013; 213: 76–80. Russian.
  20. Gaynutdinov TR. Experimental selection of doses of ionizing radiation causing growth inhibition and full inactivation of golden stafilokok. Veterinarny Vrach. 2020; 4: 4–8. DOI: 10.33632/1998698X.2020-4-4-8. Russian.
  21. Smith WW, Alderman IM, Gillespie RE. Increased survival in irradiated animals treated with bacterial endotoxins. Am J Physiol. 1957; 191 (1): 124–30. DOI: 10.1152/ajplegacy.1957.191.1.124.
  22. Pluznik DY. Benefecial effect on endotoxins. Immunobiology and Immunopharmacology of Bacterial Endotoxins. 1986; 7: 124–8. DOI: 10.1007/978-1-4613-2253-5.
  23. Ledney GD, Wilson R. Protection induced by bacterial endotoxin against whole body X-irradiation germfree and conventional mice. Proc Soc Exptl Biol Med. 1996; 118 (4): 1062–5. DOI: 10.3181/00379727-118-30046.
  24. Almagambetov KKh. Molecular biology of Staphylococcus aureus. Meditsinskiy zhurnal Astana. 2021; 1 (107): 61–8. Russian.
  25. Neta R. Role of cytokines in radioprotection. Pharmacology end Therapeutics. 1988; 39 (1–3): 261–6. DOI: 10.1016/0163-7258(88)90070-8.
  26. Grebenyuk AN, Strelova OYu, Legeza TI, Stepanova EN. Osnovy radiobiologii i radiatsionnoy meditsiny: uchebnoe posobie. SPb.: OOO «Izd-vo FOLIANT», 2012; p. 232. Russian.
  27. Gallyamova MYu, Vagin KN, Gaynutdinov TR, Rakhmatullina GI, Ryzhkin SA. The effect of multiple ionizing radiation on the activity of antioxidant enzymes of Escherichia coli ”PL-6” cells. Radiation and risk. 2024; 33 (1): 68–76. DOI: 10.21870/0131-3878-2024-33-1-68-76. Russian.
  28. Gaupp R, Lei S, Reed JM, Peisker H, Boyle-Vavra S, Bayer AS, et al. Staphylococcus aureus metabolic adaptations during the transition from a daptomycin susceptibility phenotype to a daptomycin nonsusceptibility phenotype. Antimicrobial agents and chemotherapy. 2015; 59 (7): 4226–38. DOI: 10.1128/AAC.00160-15.
  29. Linder H, Holler E, Ertl B, Multhoff G, Schreglmann M, Klauke I, et al. Peripheral blood mononuclear cells induce programmed cell death in human endothelial call and may prevent repair: role of cytokines. Blood. 1997; 29 (6): 1931–8. PubMed PMID: 9058713.
  30. Neta R, Oppenheim J. The role of cytokines in immunoregulation. Cancer call. 1991; 3 (10): 391–6. DOI: 10.1016/0163-7258(88)90070-8.