Author contribution: Shkaeva IE — study planning, literature analysis, data interpretation, rationale for setting the exposure standard, manuscript writing; Dulov SA — study planning, overall management; Nikulina OS, Solnceva SA — literature analysis, toxicological testing, data acquisition and analysis, manuscript writing; Zemlyanoi AV — research management, manuscript writing.

Compliance with ethical standards: laboratory animals were kept and fed in accordance with “Guidelines for Keeping Laboratory Animals in Vivariums of Research Institutes and Educational Institutions” (RD-APC 3.10.07.02-09 dated 15.12.2009), as well as with “Sanitary and Epidemiological Requirements for the Device, Equipment and Maintenance of Experimental Biological Clinics (Vivariums)” (SP 2.2.1.3218-14 dated 29.08.2014).