METHOD

Experimental justification of the maximum possible concentration (MPC) of dichlorohexafluorobutene in a working area

Shkaeva IE, Dulov SA, Nikulina OS, Solnceva SA, Zemlyanoi AV
About authors

Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, St. Petersburg, Russia

Correspondence should be addressed: Svelana A. Solnceva
Kapitolovo, str. 93, r.p. Kuzmolovsky, Vsevolozhsky r., Leningradskaja obl., 188663; ur.xobni@47.avecnlos

About paper

Author contribution: Shkaeva IE — study planning, literature analysis, data interpretation, rationale for setting the exposure standard, manuscript writing; Dulov SA — study planning, overall management; Nikulina OS, Solnceva SA — literature analysis, toxicological testing, data acquisition and analysis, manuscript writing; Zemlyanoi AV — research management, manuscript writing.

Compliance with ethical standards: laboratory animals were kept and fed in accordance with “Guidelines for Keeping Laboratory Animals in Vivariums of Research Institutes and Educational Institutions” (RD-APC 3.10.07.02-09 dated 15.12.2009), as well as with “Sanitary and Epidemiological Requirements for the Device, Equipment and Maintenance of Experimental Biological Clinics (Vivariums)” (SP 2.2.1.3218-14 dated 29.08.2014).

Received: 2021-05-29 Accepted: 2021-06-13 Published online: 2021-06-23
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  1. Uzhdavin JeR. Toksikologija i gigiena vysokomolekuljarnyh soedinenij i himicheskogo syr'ja. M., 1966; s. 71–72. Russian.
  2. Filov VA, redaktor. Vrednye himicheskie veshhestva. Uglevodorody, galogenproizvodnye uglevodorodov: spravochnik. L.: Himija, 1990; 732 s. Russian.
  3. Lazarev NV, redaktor. Vrednye himicheskie veshhestva. Organicheskie veshhestva: spravochnik, T. 1. L.: Himija, 1976; 300 c. Russian.
  4. Fluorocarbons in Lower Atmosphere. EOS Trans Amer Geophys Union. 1979; 60 (50): 1030.
  5. RTECS(R) National Institute for Occupational Safety and Health. Canadian Centre for Occupational Health Safety, 2005. Aailable from: https://www.cdc.gov/niosh/index.htm.
  6. Clayton JW. Toxicology of the fluoroalkenes. Review and research needs Environmental Health Perspectives. 1977; 21: 255–67.
  7. Lock EA, Berndt WO. Studies on the Mechanism of Nephrotoxicity and Nephrocarcinogenicity of Halogenated Alkenes. CRC Critical Reviews in Toxicology. 1988; 19 (1): 23–42.
  8. Truhaut R, Boudene C, Jouany J, Bouant A. Experimental study of the toxicity of a fluoroalkene derivative, the hexafluorodichlorobutene (HFCB). Fluoride. 1972; 5 (1): 4–14.
  9. Gizhlarjan MS, Darbinjan NA. Metabolicheskaja aktivacija hlorzameshhennyh nenasyshhennyh soedinenij. V sbornike: Tezisy dokladov 1-go Vses. s"ezda toksikologov, Rostov-na-Donu, 1986 g. Rostov-na-Donu, 1986; s. 293–4.
  10. Dekant W, et al. Bacterial-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. Chem-Biol Interact. 1986; 60: 31–45.
  11. Anders MW, et al. Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. CRC Crit Rev Toxicol. 1988; 18: 311–41.
  12. Hayes JD, Pulford DJ. The Glutathione S-Transferase Supergene Family: Regulation of GST* and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Critical. Reviews in Biochemistry and Molecular Biology. 1995; 30 (6): 445–600.
  13. Dreehen B, Westphal G. Mutagenicity of the glutathione and cysteine S-conjugates of the haloalkenes 1,1,2-trichloro-3,3,3trifluoro-1-propene and trichlorofluoroethene in the Ames test in comparison with the tetrachloroethene-analogues. Mutation Research. 2003; 539: 157–66.
  14. Predel'no dopustimye koncentracii (PDK) vrednyh veshhestv v vozduhe rabochej zony. Gigienicheskie normativy GN 2.2.5.1313 — 03. M.: RRPOHBV Minzdrava Rossii, 2003. Russian.
  15. Predel'no dopustimye koncentracii (PDK) vrednyh veshhestv v atmosfernom vozduhe naselennyh mest. Gigienicheskie normativy GN 2.1.6.1338-03. M.: STK Ajaks, 2003. Russian.
  16. Metodicheskie ukazanija po ustanovleniju orientirovochnyh bezopasnyh urovnej vozdejstvija v vozduhe rabochej zony. M., 1985. Russian.