ISSN Print 2713-2757
ISSN Online 2713-2765
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
In vivo toxicity study of dialkyl disulphides
About authors
1 Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, St. Petersburg, Russia
2 Mechnikov North-Western State Medical University, Saint Petersburg, Russia
Correspondence should be addressed: Semen A. Kucherskoy
Kapitolovo station, bld. 93, p/o Kuzmolovsky, Vsevolozhsky District, Leningrad reg., 188663; ur.hcepg@ioksrehcuk
About paper
Acknowlegements: we would like to thank Shkaeva IE, the leading researcher at the Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA, for study management, and Nikolaev AI, the leading researcher at the Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA, for assistance in mathematical processing of the results.
Author contribution: Kucherskoy SA – conducting toxicology studies.
Compliance with ethical standards: the study was approved by the Ethics Committee of the North-Western State Medical University named after I.I. Mechnikov (protocol № 8 dated November 11, 2020); laboratory animals were kept and fed in accordance with SP 2.2.1.3218-14 “Sanitary and Epidemiological Requirements for the Device, Equipment and Maintenance of Experimental Biological Clinics (Vivariums)”, as well as with the «Guide for Care and Use of Laboratory Animals» (USA).
Received: 2021-05-29
Accepted: 2021-06-15
Published online: 2021-06-25
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Table 1. Physical and chemical properties of dialkyl disulphide samples
Note: DMDS — dimethyl disulphide; MEDS — methylethyl disulphide; DEDS — diethyl disulphide.
Table 2. Dialkyl disulphide acute toxicity parameters with intragastric injection
Table 3. Dialkyl disulphide acute toxicity parameters with single intraperitoneal injection in male rats (n = 10)
Table 4. Dialkyl disulphide acute toxicity parameters with single inhalation exposure
