Acknowlegements: we would like to thank Shkaeva IE, the leading researcher at the Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA, for study management, and Nikolaev AI, the leading researcher at the Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA, for assistance in mathematical processing of the results.

Author contribution: Kucherskoy SA – conducting toxicology studies.

Compliance with ethical standards: the study was approved by the Ethics Committee of the North-Western State Medical University named after I.I. Mechnikov (protocol № 8 dated November 11, 2020); laboratory animals were kept and fed in accordance with SP 2.2.1.3218-14 “Sanitary and Epidemiological Requirements for the Device, Equipment and Maintenance of Experimental Biological Clinics (Vivariums)”, as well as with the «Guide for Care and Use of Laboratory Animals» (USA).