2021 / 02

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DOI: 10.47183/mes.2021.015

ORIGINAL RESEARCH

In vivo toxicity study of dialkyl disulphides

Kucherskoy SA1,2, Alikbaeva LA2
About authors

1 Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency, St. Petersburg, Russia

2 Mechnikov North-Western State Medical University, Saint Petersburg, Russia

Correspondence should be addressed: Semen A. Kucherskoy
Kapitolovo station, bld. 93, p/o Kuzmolovsky, Vsevolozhsky District, Leningrad reg., 188663; ur.hcepg@ioksrehcuk

About paper

Acknowlegements: we would like to thank Shkaeva IE, the leading researcher at the Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA, for study management, and Nikolaev AI, the leading researcher at the Research Institute of Hygiene, Occupational Pathology and Human Ecology of the FMBA, for assistance in mathematical processing of the results.

Author contribution: Kucherskoy SA – conducting toxicology studies.

Compliance with ethical standards: the study was approved by the Ethics Committee of the North-Western State Medical University named after I.I. Mechnikov (protocol № 8 dated November 11, 2020); laboratory animals were kept and fed in accordance with SP 2.2.1.3218-14 “Sanitary and Epidemiological Requirements for the Device, Equipment and Maintenance of Experimental Biological Clinics (Vivariums)”, as well as with the «Guide for Care and Use of Laboratory Animals» (USA).

Received: 2021-05-29 Accepted: 2021-06-15 Published online: 2021-06-25
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  1. Rahimov TH. Sovershenstvovanie processa pervichnoj pererabotki nefti i gazovogo kondensata s polucheniem serosoderzhashhih soedinenij i uglevodorodov [dissertacija]. Ufa, 2020. Russian.
  2. Meshhakova NM, Benemanskij VV. Ocenka biologicheskogo dejstvija dimetildisul'fida s uchetom specificheskih otdalennyh jeffektov. Bjulleten' VSNC SO RAMN. 2005; 2: 209–12. Russian.
  3. Jurkevich ES, Prismotrov YuA. Nauchnoe obosnovanie orientirovochno bezopasnogo urovnja vozdejstvija dimetildisul'fida v vozduhe rabochej zony. Zdorov'e i okruzhajushhaja sreda. 2009; 13: 515– 21. Russian.
  4. Obzor rynka disul'fidnogo masla v Rossii. M.: Infomajn, 2012; 107 s. Russian.
  5. Morgott D, Lewis C, Bootman J, Banton M. Disulfide oil hazard assessment using categorical analysis and a mode of action determination. Int J Toxicol. 2014; 33 (1): 181–98.
  6. Munday R. Harmful and beneficial effects of organic monosulfides, disulfides, and polysulfides in animals and humans. Chem Res Toxicol. 2012; 25 (1): 47–60.
  7. Valavanidis A, Vlahogianni T, Dassenakis M, Scoullos M. Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotoxicol Environ Saf. 2006; 64 (2): 178–89.
  8. Djusengaliev KI. Fiziko-himicheskie harakteristiki substitutov disul'fidnogo masla uglevodorodnogo syr'ja. Neftjanoe delo. 2016; 5: 125–39. Russian.
  9. Metodicheskie ukazanija dlja opredelenija orientirovochnyh bezopasnyh urovnej vozdejstvija (OBUV) v atmosfernom vozduhe naselennyh mest. M., 1982; 17 s. Russian.
  10. Vrednye veshhestva: klassifikacija i obshhie trebovanija bezopasnosti. GOST 12.1.007.–76. M., 1976; 6 s. Russian.
  11. Klassifikacija opasnosti himicheskoj produkcii. Obshhie trebovanija. GOST 32419-2013. M.: Standartinform, 2014; 25 s. Russian.