2021 / 03

Next Paper
DOI: 10.47183/mes.2021.028

ORIGINAL RESEARCH

BCL-2, CDKN1A and ATM gene methylation in chronically exposed individuals

Blinova EA1,2, Nikiforov VS1,2, Yanishevskaya MA1, Akleyev AV1,2
About authors

1 Ural Research Center for Radiation Medicine, Chelyabinsk, Russia

2 Chelyabinsk State University, Chelyabinsk, Russia

Correspondence should be addressed: Evgenia A. Blinova
Vorovskogo, 68, korp. 1, Chelyabinsk, 454141; ur.mrcru@avonilb

About paper

Funding: the study was carried out within the framework of the State assignment of Russian Federal Medical Biological Agency “Human Cell-Mediated Immunity During Realization of Chronic Radiation Exposure Late Effects” (code 27.002.20.800).

Author contribution: Blinova EA — literature analysis, experimental procedure, data processing, manuscript writing; Nikiforov VS — literature analysis, experimental procedure, manuscript writing; Yanishevskaya MA — experimental procedure, manuscript editing; Akleyev AV — general management, manuscript writing.

Compliance with ethical standards: the study was approved by the Ethics Committee of Ural Research Center for Radiation Medicine of Russian Federal Medical Biological Agency (protocol № 2 dated July 20, 2021).The informed consent was submitted by all examined individuals.

Received: 2021-07-27 Accepted: 2021-08-29 Published online: 2021-09-21
|
  1. Spainhour JC, Lim HS, Yi SV, Qiu P. Correlation patterns between DNA methylation and gene expression in the Cancer Genome Atlas. Cancer Inform. 2019; (18): 1–11. DOI: 10.1177/1176935119828776. PMID: 30792573. PMCID: PMC6376553.
  2. Greenberg MVC, Bourchis D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019; (20): 590–607. DOI: 10.1038/s41580-019-0159-6. PMID: 31399642.
  3. Van Tongelen A, Loriot A, De Smet C. Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes. Cancer Lett. 2017; 28 (396): 130–7. DOI: 10.1016/j. canlet.2017.03.029. PMID: 28342986.
  4. Edwards JR, Yarychkivska O, Boulard M, Bestor TH. DNA methylation and DNA methyltransferases. Epigenetics & Chromatin. 2017; 10 (23): 1–10. DOI: 10.1186/s13072-017-0130-8.
  5. Kovalchuk O, Burke P, Besplug J, Slovack M, Filkowski J, Pogridny I. Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low dose X-ray irradiation. Mutat Res. 2004; 548 (1–2): 75–84. DOI: 10.1016/j.mrfmmm.2003.12.016. PMID: 15063138.
  6. Kuzmina NS. Izuchenie aberrantnogo metilirovanija v lejkocitah krovi likvidatorov avarii na ChAJeS. Radiacionnaja biologija. Radiojekologija. 2014; 54 (2): 127–39. Russian.
  7. Cho YH, Jang Y, Woo HD, Kim YJ, Kim SY, Christensen S, et al. LINE-1 Hypomethylation is associated with radiation-induced genomic instability in industrial radiographers. Environ Mol Mutagen. 2018; 60 (2): 174–84. DOI: 10.1002/em.22237.
  8. Isubakova DS, Cymbal OS, Bronikovskaja EV, Litvjakov NV, Milto IV, Tahauov RM. Metilirovanie promotorov genov apoptoza v limfocitah krovi rabotnikov, podvergavshihsja v processe professional'noj dejatel'nosti dolgovremennomu vneshnemu oblucheniju. Bjulleten' jeksperimental'noj biologii i mediciny. 2021; 171 (3); 339–43. Russian.
  9. Nikiforov VS, Blinova EA, Akleev AV. Vlijanie kompleksa faktorov radiacionnoj i neradiacionnoj prirody na profil' transkripcionnoj aktivnosti genov u lic, podvergshihsja hronicheskomu radiacionnomu vozdejstviju. Voprosy radiacionnoj bezopasnosti. 2019; 2 (94): 64–70. Russian.
  10. Degteva MO, Napier BA, Tolstykh EI, Shiskina EA, Bougrov NG, Krestinina LYu, Akleev AV. Individual dose distribution in cohort of people exposed as a result of radioactive contamination of the Techa River. Medical Radiology and Radiation Safety. 2019; 64 (3): 46–53. DOI: 10.12737/article_5cf2364cb49523.98590475.
  11. Kulis M, Esteller M. DNA methylation and cancer. Adv Genet. 2010; (70): 27–56. DOI: 10.1016/B978-0-12-380866-0.60002-2. PMID: 20920744.
  12. Jaenisch R. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003; (33): 245–54. DOI: 10.1038/ng1089. PMID: 12610534.
  13. Kuzmina NS, Lapteva NSh, Rubanovich AB. Hypermethylation of gene promoters in peripheral blood leukocytes in humans long term after radiation exposure. Environ Res. 2016; (146): 10–17. DOI: 10.1016/j.envres.2015.12.008.