Modelling myeloablative cytostatic therapy with cyclophosphamide is accompanied by gastrointestinal stasis in rats

About authors

1 State Scientific Research Test Institute of the Military Medicine of Defense Ministry of the Russian Federation, Saint-Petersburg, Russia

2 Golikov Research Clinical Center of Toxicology of the Federal Medical Biological Agency, Saint-Petersburg, Russia

Correspondence should be addressed: Timur V. Schäfer
Lesoparkovaya, 4, Saint-Petersburg, 195043; ur.xednay@refahcs

About paper

Author contribution: Schäfer TV — developing the experimental model, study planning, experimental procedure, data processing and visualization; Ivnitsky JuJu — rationale, developing the experimental model, data interpretation; Rejniuk VL — setting up the experiment. All authors contributed to discussion, manuscript writing and editing.

Compliance with ethical standards: the study was carried out in accordance with the principles of bioethics, approved by the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (ETS N 123).

Received: 2021-12-14 Accepted: 2022-01-15 Published online: 2022-01-31
Fig. 1. X-ray radiography of rats performed at different times (specified on the left, hours) after administration of cyclophosphamide in a dose of 1000 mg (routes are specified on the top: i/p — intraperitoneal; s/c — subcutaneous; i/g — intragastric) and barium sulfate (i/g, mmediately after cyclophosphamide administration). Control rats are shown on the left in each
Fig. 2. Effects of cyclophosphamide administered in a dose of 1000 mg/kg on the barium suspension passage through the rat gastrointestinal tract. Shades of the circles are proportional to the percentage of the radiopaque shadow area in the corresponding section of the gastrointestinal tract: black circles — 100% of the administered barium sulfate; white circles — no barium sulfate