2022 / 02

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DOI: 10.47183/mes.2022.018

ORIGINAL RESEARCH

Subpopulation composition of T-helpers in the peripheral blood of persons chronically exposed to radiation in the long term

Kotikova AI1,2, Blinova EA1,2, Akleyev AV1,2
About authors

1 Ural Research Center for Radiation Medicine, Chelyabinsk, Russia

2 Chelyabinsk State University, Chelyabinsk, Russia

Correspondence should be addressed: Alisa I. Kotikova
Vorovskogo, 68, str. A, Chelyabinsk, 454141, Russia; moc.liamg@asilaavokitok

About paper

Funding: the work was carried out as part of the "State of human cellular immunity against manifestation of the long-term effects of chronic exposure to radiation" State Task (code 27.002.20.800).

Author contribution: Kotikova AI — methodology development, laboratory research, statistical processing, article authoring; Blinova EA — methodology development, article authoring; Akleyev AV — development of the research concept, scientific supervision, article authoring.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Urals Research Center for Radiation Medicine (Minutes #1 of April 14, 2022). All participants signed a voluntary informed consent to participate in the study.

Received: 2022-04-15 Accepted: 2022-05-12 Published online: 2022-06-04
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Fig. 1. Dependence of the relative amounts of peripheral blood TNaive (A) and TEM (B) on age, exposed individuals; linear regression
Fig. 2. Dependence of the content of double positive Tfh17 in TCM (A) and TEM (B) subpopulations (peripheral blood) on age (as of the time of the study), control group; linear regression
Fig. 3. Dependence of the relative amounts of peripheral blood TNaive (A) and TEM (B) on age, exposed individuals, at the beginning of exposure; linear regression
Table 1. Characteristics of the studied groups
Note: n — the number of subjects; M ± SE — mean ± standard error.
Table 2. Phenotype characteristics of the studied T helper subpopulations, peripheral blood of exposed individuals
Table 3. The number of T helpers of different subpopulations in the compared groups
Table 4. Relative number (%) of TCM population T helpers (data for the study participants)
Table 5. Relative number (%) of TEM population T helpers (data for the study participants)
Table 6. Dependence of indicators of various subpopulations of T helpers on the age of participants (as of the time of the study)
Note: S (p) — the Spearman's rank correlation coefficient (correlation significance level); R (p) — Pearson linear correlation coefficient (correlation significance level).